White adipose tissue (WAT) and brown adipose tissue (BAT) are tasked with disparate functions. BAT is a thermogenic tissue comprised of multilocular cells, responsible for heat generation and regulation. The composition of the BAT cell is well equipped for this function due to significant ...
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we show that the VAT harbors two distinct Tregcell populations: prototypical serum ...
Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies
probably contributetoATMdysfunctionandinflammatorytraits duringobesity •Identificationoftranscriptionaldifferencesbetween ATMsfromleanvsobeseadiposetissueatseveralkey pointsduringthedevelopmentofobesityandinsulinre- sistancemayrevealupstreamtriggers,regulatoryfactors andintracellularpathwaysthatshapeATMfunction •Targeting...
Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), are driven by neuroinflammation triggered by activated microglial cells; hence, the phenotypic regulation of these cells is an appealing target for intervention. Human adipose tissue-de
Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling Shangli Ji, Yanfang Peng, Jian Liu, Pang Xu & Shibo Tang Acta Neuropathologica Communications volume...
The volume retention rates for fat grafts in the stem cell-assisted fat transplantation group at 1 week, 4 week, and 12 week were significantly greater than those in the normal fat transplantation group (Fig. 1A, B). The adipose tissue from the transplantation area of mice after fat transpla...
In the case of patients undergoing reconstruction with stem cell-enriched samples, stem cell isolation was performed from aliquots of either non-enriched adipose tissue samples (that is, collected before stem cell enrichment procedures) or stem cell-enriched adipose tissue samples. Lipoaspirates were ...
cell types with very little attention paid to the organization and putative partitioning of cells. Considering the absence of a complete picture of the intimate architecture of this large soft tissue, we developed a method that combines tissue clearing, acquisition of autofluorescence or lectin signals...
The fate of human adipose tissue stem cells (ASCs) is largely determined by biochemical and mechanical cues from the extracellular matrix (ECM), which are sensed and transmitted by integrins. It is well known that specific ECM constituents influence ASC