Macrophages and dendritic cells (DCs) are well equipped to sense environmental cues and play dominant roles in tissue homeostasis and inflammation. Macrophages comprise the most abundant leukocyte population in
Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators ofCOL6A3expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes ...
It was concluded that in vivo determined adipocyte precursor cells (preadipocytes, lipid-free fat cells) are not present in a significant number in human adipose tissue either from adults or from children as tested with the method employed, allowing detection of a large number of such cells in...
The major WAT depots are classified according to their anatomic location as either subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT). Adipocytes, as the most dominant component of WAT, are consist of mature adipocytes and adipose stem and progenitor cells (ASPCs), which are the...
Adipose tissue is a specialized connective tissue that is comprised of lipid-filled cells (adipocytes) contained within a collagen framework. From: Physical Medicine and Rehabilitation Clinics of North America, 2007 About this pageSet alert Also in subject areas: Agricultural and Biological Sciences Ear...
Normal adipose tissue cells are found in fragments or clusters in smears showing large fat cells with abundant univacuolated cytoplasm and small dark regular nuclei. In the larger fragments a discrete network of slender capillaries may be observed. Dissociated fat cells are quite uncommon. The larg...
Methods of preventing, delaying, or reducing the development or severity of obesity-associated disorders, including administering Fat-specific regulatory T cells, or administering factors secreted by said T cells.FEUERER MARKUSMATHIS DIANE J.SHOELSON STEVENBENOIST CHRISTOPHE O....
Adipose tissue is a complex organ that comprises a wide range of cell types with diverse energy storage, metabolic regulation, and neuroendocrine and immune functions. Because it contains various immune cells, either adaptive (B and T lymphocytes; such as regulatory T cells) or innate (mostly mac...
FMO1 was abundantly expressed in the metabolic tissue (especially liver) of pigs and rabbits but was not expressed in adult humans59. Consistent with this previous study, we found that FMO1 interacted with 16 enhancers in porcine SAT (four were specific to the pig genome, nine had conserved ...
The perivascular adipose tissue (PVAT) differs from other fat depots and exerts a paracrine action on the vasculature. The spleen has an important role in the immune response, and it was observed to have either a protective role or a contribution to obesity-related diseases. However, the relat...