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EVs have become a crucial new method of cellular communication and a pathway for the exchange of bioactive chemicals [25]. Emerging evidence suggests that EVs play a significant role in the interaction between adipocytes and tumor cells, complementing soluble substances. ADEVs increase the aggressivenes...
In particular, these programs are finely tuned for H&E images whereby the brightest portion of the cell is the cell membrane. However, this is not the case in immunofluorescent imaging where there are intensity gradients within the cells along with variability from cell to cell25. Further, H...
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To differentiate 3T3-L1 pre-adipocytes into adipocytes (3T3-L1A), cells were cultured in pre-adipocytes growth medium for 3 days and then incubated for 48 h in differentiation medium (1 μM Dexamethasone, 0,5 mM 3-Isobutyl-1-Methylxanthine and 1 μg/ml bovine insulin). After 14 days ...
However, since mature adipocytes cannot be distinguished using scRNA-seq approaches, they were hardly found in the hVAT and hSAT atlases [8]. Fig. 1 A single-cell atlas of mouse and human WAT. A Schematic of workflows for the scRNA-seq/snRNA-seq analysis of mouse and human WAT. B ...
Reagents, cell culture, cell viability assay, small interfering RNA transfection and cell treatment, real time RT-PCR, H&E staining, immunofluorescent assay, neutrophil migration assay, western blotting, Th17 cell differentiation, and Oil Red O staining are described in the Supplementary Materials and...
To determine the effect of WAT inflammation on glucose and lipid metabolism in hepatocytes, we introduced M1-iMACs into iADIPO-MPS for 24 h at an M1-iMAC-iADIPO ratio of 1:10 before interconnection to iHEP-MPS at an iADIPO-iHEP ratio of 5:1. After 48 h of interconnection, the ...
caloric excess is dependent on IL1R1. No major changes in abundance of adipocyte progenitor populations were observed in IL1R1-KO mice (Supplementary Fig.3e–h). Further, we found that transient pharmacological inhibition of IL-1 signaling, starting at 8 weeks of age, increased EdU ...