, the Austrian Fonds zur Förderung der Wissenschaftlichen Forschung (F73 SFB Lipid Hydrolysis to R.Z.) and the Louis Jeantet Prize 2015 by the Fondation Louis Jeantet to R.Z. Author information Authors and Affiliations Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina...
Note:When the body requires additional energy, the droplets of triglycerides contained in adipocytes undergo enzymatic hydrolysis to produce free fatty acids and glycerol. Love words? Need even more definitions? Subscribe to America's largest dictionary and get thousands more definitions and advanced sea...
HSL, the rate-limiting enzyme regulating adipocyte lipolysis, then catalyzes the hydrolysis of triglycerides and results in the release of glycerol and FFA (increased lipolysis). Phosphodiesterases (PDE) are enzymes that hydrolyze cAMP to 5'-AMP (5 prime adenosine monophosphate). This action results...
The beta-adrenergic/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signalling pathway plays a crucial role in controlling the catabolic phenotype of adipose tissues by regulating lipolysis14, oxidative gene transcription15, and mitochondrial oxidative metabolism16. Indeed, activation of the ...
this reason, we identified only ether phosphatidylcholine peaks disappearing during acid hydrolysis as plasmenyl PC, using the fact that plasmalogen is unstable in the acidic environment. Theexample of standard fragmentation and lipid annotation are provided in Supplementary Figs. 24and 25. For the...
Fatty acid release from adipocytes is dependent on sequential hydrolysis of triacylglycerol by the lipases ATGL and HSL [20]. We therefore determined the role of these lipases in mediating adipocyte-stimulated changes in breast cancer cell proliferation and migration (Fig. 5). 3T3-L1 adipocytes were...
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the...
Interestingly, DNL contributes very little to total fat deposition within the lipid droplets of adipocytes, which mostly derives from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoproteins [24], [25], [26], [66]. This suggests that DNL has other roles in the adipocyte. Its ...
HSL contributes to the lipolytic degradation of adipocyte TAG stores, being rate limiting for diacylglycerol and cholesteryl ester hydrolysis, and can also provide PPARγ ligands for normal preadipocyte differentiation to mature adipocytes [13]. Because of the striking parallels between augmented ...
Metabolic events that are linked to receptor-ligand interactions include gene transcription, phosphorylation, dephosphorylation, increases in cyclic AMP production, mobilization of cellular calcium, mobilization of membrane lipids, cell adhesion, hydrolysis of inositol lipids and hydrolysis of phospholipids. ...