Molecular mechanism driving retroperitoneal adipocyte hypertrophy and hyperplasia in response to a high-sugar diet. Mol Nutr Food Res. 2014;58:2331-41.de Queiroz K B, Coimbra R S, Ferreira A R, Carneiro C M, Paiva N C, Costa D C, Evangelista E A, Guerra‐Sa R. Molecular mechanism ...
thereby protecting the rest of the body from ectopic lipid accumulation and lipotoxicity. It achieves this task by expanding in two ways, either by enlargement of already existing adipocytes (hypertrophy), or by the formation of new adipocytes (hyperplasia). A hypertrophic WAT (few and ...
White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis). Adipogenesis results in WAT hyperplasia, smaller adipocytes and a metabolically mor
Adipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia.Although depot-specific differences and obesity-related modulation of adipocyte size ...
(at 2 weeks hyperplasia: 68.86±33.62 vs 43.57±24.47 adipocytes/mm 2 , p=0.048; at 4 weeks hypotrophy: 0.00036±0.00019 vs 0.00046±0.00023mm 2 , p=0.027), and by adipocyte hypertrophy after 16 weeks of immobilization (0.00083±0.00049 vs 0.00046±0.00028mm 2 , p=0.027) compared to ...
A cohort of genes was selected to characterize the adipogenic phenotype in primary cell cultures from three tissue sources. We compared the quantitative expression of biomarkers in culture relative to their expression in vivo because the mere presence or absence of expression is minimally informative. ...
JARID2 Expression in Adipocytes Is Influenced by Obesity and HyperplasiaLarge adipocytes (WAT hypertrophy) are indicative of lower adipogenic capacity of the tissue, as discussed (121). Therefore, we investigated whether there is any correlation between JARID2 expression and WAT morphology. In human...
HyperplasiaHypertrophyInflammationLipolysisObjective We tested the hypothesis that women with adipocyte hypertrophy in either omental (OM) or subcutaneous (SC) adipose tissue are characterized by alterations in adipocyte lipolysis and adipose tissue expression of genes coding for proteins involved in adipocyte...
Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol. 2009;5:e1000324. Article PubMed PubMed Central CAS Google Scholar Longo M, Zatterale F, Naderi J, Parrillo L, Formisano P, Raciti GA, et al. Adipose tissue dysfunction as determinant of obesity-associated...
In obesity, the adipose tissue undergoes dynamic remodeling including an increase in size (hypertrophy) and number of adipocytes (hyperplasia), an infiltration by immune cells, and the development of tissue fibrosis7,8,9,10,11,12. In the obese adipose tissue, adipocytes are exposed to different...