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Hydrogels are promising materials in tissue engineering scaffolds for healing and regenerating damaged biological tissues. Previously, we developed supramolecular hydrogels using polyrotaxane (PRX), consisting of multiple cyclic molecules threaded by an axis polymer for modulating cellular responses. However, ...
a range of structural domains are recognizable within their ligands, some of which have clearly defined functions; e.g., the well-characterized Arg-Gly-Asp (RGD) peptide motif, originally described in the proteinfibronectinand now known to be present widely in many matrix proteins (Pierschbacher...
Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of Alzheimer’s disease (AD). Previously, we reported a correlation between cell adhesion molecule L1 (L1) expression and the occurrence of AD, but its relatio
This concept was supported by our observation of perivascular co-localization of the two proteins in the early stages of the RPA response. However, after 60 minutes, this co-localization was widespread, indicating that ICs subsequently form throughout the extravascular tissue. Furthermore, the exit...
What is cell adhesion and why is it important? Cell adhesion is such a mechanism by which cells adhere to themselves and with other cells with the help of cell surface proteins. The contact can either be direct like in cell junction or it can be indirect in which cells are connected by ...
Odenbreit S, Faller G & Haas R (2002) Role of the alpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissue. ... M Skurnik,JA Bengoechea,K Granfors 被引量: 0发表: 2003年 Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric infla...
model organism Drosophila melanogaster to determine if Mbc and Spg function redundantly in tissues other than border cell migration and to establish if these Dock proteins target the same or different GTPases in the dorsal vessel (dv), a tissue where both transcripts are expressed (Biersmith et ...
in some structural motifs that are postulated to be key for class A and B1 receptor activation13. To uncover molecular details that govern the tethered agonism of the aGPCRs, we determined the structures of ADGRD1 and ADGRF1 in complex with different heterotrimeric G proteins. Together with ...
Adgrf5/Gpr116 transcripts. The domain structure of proteins derived from abundant Adgrf5/Gpr116 mRNA variants (see Fig.1) is schematically depicted. The C terminus of the receptor can also differ (red line). The exact positions of the exons forming the variants are given in suppl. TableS3...