Adhesion G protein-coupled receptors (aGPCRs) — one of the five main families in the GPCR superfamily — have several atypical characteristics, including large, multi-domain N termini and a highly conserved region that can be autoproteolytically cleaved
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci USA 2011; 108: 2534–2539. 36 Chen Y, Hancock ML, Role LW, Talmage DA. Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the ...
Schoneberg, T., Liebscher, I., Luo, R., Monk, K. R. and Piao, X. (2015). Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. J Recept Signal Transduct Res, 1-4.Schoneberg T, Liebscher I, Luo R, Monk KR, Piao X Tethered agonists: a new...
T Izard,G Evans,RA Borgon,... - 《Nature》 被引量: 395发表: 2004年 MicroRNA-205 Inhibits Src-Mediated Oncogenic Pathways in Renal Cancer The Src family of protein kinases (SFK) plays key roles in regulating fundamental cellular processes, including cell growth, differentiation, cell shape, ...
Objective;TGR5 is a G-protein-coupled receptor for bile acids. So far, little is known about the function of TGR5 in vascular endothelial cells.Approach and Results;In bovine aortic endothelial cells, treatment with a bile acid having a high affinity to TGR5, taurolithocholic acid (TLCA), sig...
We have derived a panel of CD4+, TCR-alpha/beta + T cell clones from SJL (H-2s) mice specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) 139-151 (HSLGKWLGHPDKF). All the clones are Ag specific and IAs restricted, but they show heterogeneity in their abilit...
protein kinase cascade. Direct signaling also induces ionic transients (e.g., Ca2+and Na+/H+) and stimulates lipid metabolism. In collaborative signaling, integrin–ECM adhesion modulates signaling initiated by other types of receptors, such asreceptor tyrosine kinasesand G-protein-coupled receptors,...
In an attempt to define the role of cell adhesion molecules (CAMs) within the bone marrow (BM) microenvironment in normal hematopoiesis and in leukemia development, a novel cell-blotting technique that involved cell adhesion to protein bands after separation by lithium dodecyl sulfate-polyacrylamide ...
The enormous sizes of adhesion G protein-coupled receptors (aGPCRs) go along with complex genomic exon-intron architectures giving rise to multiple mRNA variants. There is a need for a comprehensive catalog of aGPCR variants for proper evaluation of the
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperlocomotion and altered dopamine signaling. Thus, ...