Adhesion G protein-coupled receptors (aGPCRs) — one of the five main families in the GPCR superfamily — have several atypical characteristics, including large, multi-domain N termini and a highly conserved region that can be autoproteolytically cleaved
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci USA 2011; 108: 2534–2539. 36 Chen Y, Hancock ML, Role LW, Talmage DA. Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the ...
(2015). Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. J. Recept. Signal. Transduct. Res. 35, 220-223.Schoneberg, T., Liebscher, I., Luo, R., Monk, K. R. and Piao, X. (2015). Tethered agonists: a new mechanism underlying adhesion G ...
Adhesion G protein-coupled receptors (aGPCRs) belong to an inadequately characterized class of GPCRs as their enormous size limited functional investigations for a long time1,2,3. In the last decade, however, G-protein coupling4, the activation mechanism by a tethered agonist5,6, and function...
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperlocomotion and altered dopamine signaling. Thus, ...
GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth N S Bayin, J D Frenster, J R Kane, J Rubenstein, A S Modrek, R Baitalmal, I Dolgalev, K Rudzenski, L Scarabottolo, D Crespi, L Redaelli, M Snuderl, J G Golfinos...
The ADGRF5-RhoA axis, a canonical G protein-coupled receptor signaling pathway, acts as the upstream regulator that suppresses ERK1/2 activity, necessary for the inhibition of C/EBPβ phosphorylation at Thr 235, thus contributing to the inhibition of antitumorigenic MMP8 expression in breast ...
et al. Post-translational proteolytic processing of the calcium-independent receptor of α-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif. J. Biol. Chem. 277, 46518–...
Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce α and β subunits1,2,3. A tethered agonism mediated by the ‘Stachel sequence’ of the β subunit has been proposed to have central roles in aG...
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available1,2,3. Here we report that glucocorticoid stress hormones activate adhesion G-protein-coupled receptor G3 (ADGRG3; also known as GPR97)4,5,6,...