Adenosine A 2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia. 2012; 60 :702–716.Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, et al. Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes . ...
Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors. Hippocampus 17: 577–585. Dio´genes MJ, Fernandes CC, Sebastia˜o AM, Ribeiro JA (2004). Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation...
The main adenosine GPCR subtypes expressed in the brain include A1 and A2A, which are found in neurons as well as glia84 (Fig. 5-7, I). A1 receptors, which have the highest affinity for adenosine, reduce neuronal excitability by decreasing AC/cAMP activity, and, via βγ subunits, blocki...
We found that humans with Alzheimer's disease (AD) had increased levels of the Gs-coupled adenosine receptor A2A in astrocytes. Conditional genetic removal of these receptors enhanced long-term memory in young and aging mice and increased the levels of Arc (also known as Arg3.1), an immediate...
Adenosine ReceptorAutophagyHIV ProteasePDE ¥ 153 现货 规格 数量 客户已引用 CPI-444 V81444, ciforadenant T71831202402-40-1 CPI-444 (V81444) 是一种选择性的,可口服的 A2A 受体 (A2AR) 拮抗剂,可诱导抗肿瘤反应。 Adenosine Receptor ¥ 393 ...
Anti-Adenosine A2A Receptor Antibody (#AAR-002) is a highly specific antibody directed against an epitope of mouse protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize A2aR from human, rat, and mouse samples...
This raises several questions with regards to the source of adenosine, the cellular localization of A2AR and the signalling mechanism engaged to compromise LTP. On brain injury, A2AR undergo increased expression in both neurons and glia14,36; their conditional removal from astrocytes ameliorates ...
In this review, we first examine the epidemiology of caffeine in PD and follow this by examining evidence for caffeine and other, more selective antagonists of the adenosine A2A receptor as potential neuroprotective agents. Finally, we suggest how the clinical relevance of this evidence might be ...
S Humez1,2, CE Müller5, LV Lopes4, L Buée1,2,10 and D Blum1,2,10 Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models...
However, only one adenosine receptor-specific agent — the adenosine A2A receptor agonist regadenoson (Lexiscan; Astellas Pharma) — has so far gained approval from the US Food and Drug Administration (FDA). Here, we focus on the biology of adenosine signalling to identify hurdles in the ...