Adenosine A2A receptor antagonistIstradefyllineCognitive dysfunctionDopaminePrefrontal cortexParkinson's disease (PD) is primarily characterized by motor abnormalities, but cognitive changes also occur in the early and late stages of the disease process. In PD patients, cognitive dysfunction is associated ...
The triazolo[1,5-c]quinazoline (A2; MRS 1220) characterized as novel A1, A2A, and A3 (Ki = 305 ± 51, 52.0 ± 8.8 and 0.65 ± 0.25 nM, respectively) adenosine receptor antagonist (Fig. 5). However, the target triazolo[1,5-c]quinazoline (A3) displayed selective antagonist activit...
To gain insight into the mechanism by which clozapine and haloperidol induced FLI in these brain structures, we evaluated whether blockade of adenosine A2A receptors could influence these effects. The selective and high-affinity A2A receptor antagonist SCH 58261 (5 mg/kg) completely abolished FLI ...
(a) Purified human CD4+ T cells were incubated on immobilized anti-CD3/CD28 mAb with 1 U ml−1 ADA (Stimulation Control) or with adenosine analogs (ATL313, NECA) in the presence or absence of A2A antagonists (ZM241385 or SCH58261 = SCH) or ATL801, an A2B antagonist. Rolipram, ...
The aim of this work was to investigate further the mechanism of the neuroprotective action of A2A receptor antagonists in models of pre- and postsynaptic excitotoxicity. In microdialysis studies, the intrastriatal perfusion of the A2A receptor antagonist ZM 241385 (5 and 50 nM) significantly ...
产品属性:品牌:MedChemExpress (MCE);产地:美国; 产品参数: 货号:;规格...产品描述 Adenosine receptor antagonist 2 是一种口服有效的 A2a/A2b 腺苷受体拮抗剂,IC50 分别为 1 nM 和 3 nM。Adenosine receptor antagonist 2 具有抗肿瘤活性。更多产品详情查看:www.medchemexpress.cn/adenosine-receptor-antagoni...
Adenosine receptor antagonist 2 是一种口服有效的 A2a/A2b 腺苷受体拮抗剂,IC50 分别为 1 nM 和 3 nM。Adenosine receptor antagonist 2 具有抗肿瘤活性。 产品介绍 Adenosine receptor antagonist 2 是一种口服有效的 A2a/A2b 腺苷受体拮抗剂,IC50 分别为 1 nM 和 3 nM。Adenosine receptor antagonist 2 具有...
Preladenant is a potent and competitive antagonist of the humanadenosine A2Areceptor with aKiof 1.1 nM and has over 1000-fold selectivity overotheradenosine receptors. IC50& Target Ki: 1.1 nM (Adenosine A2Areceptor)[1] 体外研究 (In Vitro) ...
Because of their adenosine A2a receptor antagonist activity, compounds of the present invention are useful in the treatment of depression, cognitive function diseases and neurodegenerative diseases such as Parkinson's disease, senile dementia as in Alzheimer's disease, and psychoses of organic origin. ...
Because of their adenosine A2a receptor antagonist activity, compounds of the present invention are useful in the treatment of depression, cognitive function diseases and neurodegenerative diseases such as Parkinson's disease, senile dementia as in Alzheimer's disease, and psychoses of organic origin. ...