ADAMTS13 activity was 44.0 卤 17.8(%) (normal range, 50-150%) (Figure 1). ADAMTS13 activity was mildly decreased in all patients, and was under normal levels in 8 patients. There were no subjects under 10% in ADAMTS13 activity, the baseline level referred to thrombotic thrombocytopenic ...
Considerable progress has also been realized toward understanding the role of ADAMTS13 in normal hemostasis, as well as the mechanisms by which ADAMTS13 deficiency contributes to TTP pathogenesis. Measurement of ADAMTS13 activity in TTP and other pathologic conditions also remains a focus of a ...
Total reaction volumes of 100 µL containing ADAMTS13-BirA* or BirA* (100 nM) or no protein (PBS—phosphate-buffered saline: 137 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, and 1.8 mM KH2PO4), containing 90 µL citrated pooled normal plasma (PNP), ATP (1 mM / hour) and biotin (...
Collagen Binding Assays. Normal plasma or purified vWF is incubated with the test plasma sample in the presence of BaCl2and 1.5M urea which denatures the vWF. VWF is cleaved by ADAMTS-13 and residual vWF is measured by its binding to collagen Type III. The bound vWF is quantitated using ...
This hypothesis may also be supported by the decreased ADAMTS13 levels in AML and ALL patients compared to those in normal individuals [11,12]. Furthermore, it is suggested that endothelial dysfunction due to the increased vWF activity may be related to the progress of acute leukemia [23,24]...
Test results for antibodies against both proteins were positive. While plasma exchange therapy was continued, rituximab was given once weekly for four consecutive weeks. After the last dose, thrombocytes and activities of ADAMTS-13 and factor H increased into the normal range. Our patient ...
ADAMTS13 assays are often used for supporting the diagnosis, here we present a rare case of TTP with normal ADAMTS13 levels. Case presentation: A 39-year-old female presents with syncopal episodes, blurred vision in both eyes during a patch test, headaches, and tenderness over the abdomen, ...
Test results for antibodies against both proteins were positive. While plasma exchange therapy was continued, rituximab was given once weekly for four consecutive weeks. After the last dose, thrombocytes and activities of ADAMTS-13 and factor H increased into the normal range. Our patient ...
Normal range for VWF activity, 50% to 187%. LL, lower limit of normal; UL, upper limit of normal. Cost-saving potential This study used a multimodal cost analysis, as indicated in the Methods section and the legend to supplemental Table 2.13, 14 A global analysis summarizes the cost-...
Dotted red lines denote the upper and lower limit of the local reference range, with green shaded area falling within normal limits. Data are presented as median and the IQR. Comparisons between groups were assessed by the Mann-Whitney U test. Correlations between plasma VWF:Ag levels and (E...