<0.01),r1P患者血浆ADAMTS-13活性水平阳性率[68.57%(24/35)]明显低于TTP患者[100%(6/6)](P<0.01)。结论 AD&MTS-13活性水平检测在ⅡP与TTP鉴别诊断中具有一定的意义。 关键词:特发性血小板减少性紫癜;血栓性血小板减少性紫癜;vWF裂解蛋白酶活性
Aim: Analysis of the ADAMTS‐13 antigen levels in TTP patients compared with normal donors. Methods: An antigen ELISA test was built, based on high affinity anti‐ADAMTS‐13 monoclonal antibodies, which were generated using genetic immunization. Results: Specificity of the ADAMTS‐13 antigen test ...
患者中的表达情况,鉴别出免疫介导性获得性TTP,为临床免疫抑制治 疗提供实验室依据。方法:用残余胶原结合试验(R-CBA)检测患者血浆 标本ADAMTS13活性及其抑制物试验。结果:20例ITTP患者中18例 ADAMTS13活性低于10%,与正常对照组比较,差异有统计学意义(P<); ...
结果 SLE 及 1vrP 患者血浆 ADAMTS-13 活性水平[ (71. 34 ± 12. 85) %、 (12. 54 ± 11. 69) %]显著低于正常人[ (78. 60 ± 10. 03) %]( P < 0. 01), SLE 血浆 ADAMT S-13 活性水平明显高于 TTP 患者( P < 0. 01) , sl E 血浆 ADA... ...
0.01),thelevelofADAMTS-13activityintheSLEW3SsignificantlyhigherthanthatofTTP( P< 0.O1),thepositivityrateoftheADAMTS一 13activityinthepatientswithSLE[18.42%(7/38)]W3S significantlylowerthanthatofTTP[100%(6/6)](P<0.01).ConclusionDetectingADAM ...
Aim: Analysis of the ADAMTS-13 antigen levels in TTP patients compared with normal donors. Methods: An antigen ELISA test was built, based on high affinity anti-ADAMTS-13 monoclonal antibodies, which were generated using genetic immunization. Results: Specificity of the ADAMTS-13 antigen test was...
Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patientsdoi:10.1016/j.leukres.2016.12.004ADAMTS-13AMLInfectionInflammationDICADAMTS-13 is crucial for maintaining the normal size of vWF. Besides thrombotic thrombocytopenic purpura (TTP), decreased ...
replacement therapy with infusions of either fresh-frozen or solvent/detergent-treated plasma, the level of ADAMTS13 that can be achieved is restricted by infusion volume, and patients can also experience adverse reactions to plasma ... N Jain,C Marquez,L Martell - 《Blood》 被引量: 0发表:...
得性ADAMTS13的缺失相关的血栓性血小板减少性紫癜(TTP)。制备鼠源性的抗人 ADAMTS13的单抗对于研究ADAMTS13的功能至关重要。 方法:利用真核表达的重组ADAMTS13截短型蛋白(ADAMTS13-T7)纯品免疫Balb/c 小鼠,经标准单克隆抗体技术制备单抗。用ELISA方法鉴定单抗的特异性,利用免 疫印迹技术确定单抗与全长ADAMTS13的识...
In addition, the likelihood of relapse was 3.6 times higher when patients had both severe ADAMTS13 deficiency and anti-ADAMTS13 antibodies [27]. Using a logistic regression model, Jin et al. assessed the relationship between ADAMTS13 activity level and the probability of iTTP relapse in 157 ...