This chapter gives a review of ADAMTS13 testing, which is used as a diagnostic test for thrombotic thrombocytopenia prupura (TTP) and it discusses the activity of ADAMTS13 and the assessment for the presence of an inhibitor to the ADAMTS13 enzyme. The various methods for testing of ADAMTS13 ...
摘要:目的:建立血管性血友病因子裂解蛋白酶(ADAMTS13)活性及其抑制物测定方法,研究其在原发性血栓性血小板减少性紫癜(ITTP)患者中的表达情况,鉴别出免疫介导性获得性TTP,为临床免疫抑制治疗提供实验室依据。方法:用残余胶原结合试验(R-CBA)检测患者血浆标本ADAMTS13活性及其抑制物试验。结果:20例ITTP患者中18例ADAMTS...
Measurement of ADAMTS13 activity in TTP and other pathologic conditions also remains a focus of a substantial clinical research effort. Building on these studies, continued investigation of ADAMTS13 and VWF holds considerable promise for advancing the understanding of TTP pathogenesis and should lead to...
“Our new HemosIL ADAMTS13 Activity Assay is a true reflection of our mission to enhance patient care through innovation. With significantly faster results, it offers tremendous improvements in the diagnosis and treatment of TTP,” said Remo Tazzi, Director of Worldwide Ma...
12.根据权利要求11所述的方法,其中所述风险因素为VWF血浆含量升高、超大型多聚 体(UHMW)VWF多聚体血浆含量升高、血浆VWF活性含量升高、内源性ADAMTS13血浆含量降低、 内源性ADAMTS13的活性降低、细胞因子含量升高、凝血病变、凝血障碍、静脉闭塞症、血栓前 病状、遗传性血栓性血小板减少性紫癜(TTP)、后天性TTP、...
We also sought to investigate the effect of anti‐β2GPI antibodies on ADAMTS13 activity as ADAMTS13 dysfunction, which classically results in microvascular thrombi such as that seen in TTP, has been recently linked to thromboembolic events such as myocardial infarction, DVT, and stroke.38-40 In...
Insufficient ADAMTS13 activity can lead to unregulated VWF platelet-capturing and is a risk factor for thrombosis including thrombotic thrombocytopenic purpura (TTP), myocardial infarction, stroke, and venous thromboembolism1,2,3,4. Excessive VWF degradation by ADAMTS13 can be associated with bleeding ...
多克隆抗体介导的获得性ADAMTSl3缺陷小鼠模型的建立 摘 要 目的: 血栓性血小板减少性紫癜(thrombotic thrombocytopenicpurpura, TTP)是一种临床上少见但严重危及患者生命的血栓性微血管病。其主要 临床特征为血小板计数减低、微血管病性溶血性贫血、神经精神症状、肾 脏损害和发热。如前三者同时存在称之为TTP“三联症”...
Thrombotic thrombocytopenic purpura (TTP) is a particularly serious form of thrombotic microangiopathy (TMA) due to the risk of multiple organ dysfunction... Hubert,Yao,Matthieu,... - 《Clinical Nephrology》 被引量: 12发表: 2014年 ADAMTS13 and Von Willebrand factor in patients undergoing hemodial...
FIG. 1 depicts the ADAMTS-13 Rapid test principle. FIG. 2 the test results for a non TTP Patient compared with a TTP patient. FIG. 3 shows the results of an experiment in which the binding of G7 antibody to vWF coated plates was tested. Microtiter plates were coated with three differen...