Machaon provides the fastest ADAMTS13 activity and inhibitor testing available in the US. Rapid diagnosis and administration of correct treatment is paramount for TTP and aHUS. This test is diagnostic for Thrombotic Thrombocytopenic Purpura (TTP) when ADAMTS13 Activity levels are below 10%. Consider ...
activityof18caseswaslessthan10%,comparedwiththe normalgroup(P<);furthermore,ininhibitortest15casesof themwerewithpositiveresults.Conclusion:ITTPpatients haveextremelyloworevenlackofADAMTSI3activity,and ADAMTS13inhibitorisalsodetectedintheplasmafrommost ...
Decreased ADAMTS 13 activity is associated with disease severity and outcome in pediatric severe sepsis[J]. Medicine(Baltimore), 2016, 95(16):e3374. DOI: 10.1097/MD.0000000000003374. [35] LancellottiS, BassoM, VecaV, et al. Presence of portal vein thrombosis in liver cirrhosis is strongly ...
eclampsia — eclampsia ,which indicates that decrease of A D A MTS1 3 activity ind uced by eclampsia may be au import ant factor pf maternal blood coagulation d isord ers or even DIC ,which provid es a new therapeutic target for treatment of eclampsia. ...
ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study. Diabetologia. 2017;60(2):280-6.de Vries PS, van Herpt TT, Ligthart S, Hofman A, Ikram MA, van Hoek M, et al. ADAMTS13 activity as a novel risk factor for incident type...
V 英文摘要 造血干细胞移植过程中ADAMTS13 活性与抑制物的检测及其临床意义;75 例外周T 细胞淋巴瘤患者的预后与相关因素分析 (2)Using FRETS-VWF73 assay,we detect the ADAMTS13 activity of 113 patients at two period (before the transplantation pretreatment, after pretreatment). (3)We detect the ADAMTS...
ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) is a secreted multi-domain zinc protease primarily produced by the liver. In the circulation, it is responsible for cleaving von Willebrand factor (vWF) between Tyr842 and Met843. Defects in ADAMTS13 activity result in th...
Low ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the association of either VWF or ADAMTS13 with ...
(FurlanM,RoblesR,SolenthalerM,ffassmerΜ,SandozΡ,LaemmleΒ.Deficientactivityofvonffillebrandfactor-cleavingproteaseinchronicrelapsingthromboticthrombocytopenicpurpura.Blood.1997;89:3097-3103;TsaiΗM,Sussman,II,GinsburgD,LankhofH,SixmaJJ,NagelRL.Proteolyticcleavageofrecombinanttype2AvonffillebrandfactormutantsR...
factor, the ratio of activity vWF/ADAMTS13 levels and the score of the APACHEII were increased in the 3ds in survival group , the activity of the A disintegrin-like and metalloprotease with thrombospondin type 1 motif was decreased in the 3ds in survival ...