Intraplaque injection of p53 gene provides a safe and effective method for inducing plaque vulnerability in rabbits. The destabilizing effect of p53 overexpression is mediated mainly through apoptosis-enhanced inflammation rather than cell apoptosis itself....
a phase 2 trial of surgery with perioperative ingn 201 (ad5cmv-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx:objectivein patients with advanced squamous cell carcinoma of the head and neck (...
status to to p53 in NPC. mutated majority primary of reports derived indicate (16, but there protein The but with cell p53 gene of recombinant protein expression when treated with of recombinant levels observed was expression p53 also were also observed in the NPC cell lines Ad5CMV-p53 at ...
GenetherapyIonizingradiationp53ProstatecancerAdenovirusPurpose: The aim of this study was to investigate the efficacy of combination therapy of ionizing radiation (IR) and adenoviral p53 gene therapy and to evaluate its molecular mechanisms. Methods and Materials: Two human prostate cancer cell lines, ...
Modulation of drug cytotoxi2 city by reintroduction of wild2type p53 gene (Ad5CMV2p53) in hu2 man pancreatic cancer J . Cancer Gene Ther , 2000 , 7 (4) : 5452 56.Cascallo M,Calbo J,Gelpi J L. Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) ...
Introgen's adenoviral p53 gene therapy [INGN 201, ADVEXIN庐] is in clinical development for the treatment of various cancers. The p53 tumour suppressor gene is deleted or mutated in many tumour cells and is one of the most frequently mutated genes in human tumours. INGN 201 has been ...