In oligodendrocytes treated with A尾1-42, overexpression of AK5 resulted in elevated levels of P-AMPK, SIRT1, and BCL-2 proteins, while reducing the levels of BAX, CASPASE-3, and NF-魏B proteins. This modulation activated AMPK signaling, thereby inhibiting neuroinflammation and apoptosis. In ...
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单细胞测序:骨科疾病诊治的新思路 单细胞测序(single cell sequencing)是在单个细胞水平上,对基因组或转录组进行扩增并测序,以检测单核苷酸位点变异(SNV)、基因拷贝数变异(CNV)、单细胞基因组结构变异、基因表达水平、基因融合、单细胞转录组的选择性剪切、单细胞表观基因组...
单细胞测序技术(Single cell RNA sequencing,scRNA-seq)是指在单个细胞水平上,对基因组、转录组、表观组等遗传信息进行高通量测序分析的一项新技术,可以研究单个细胞内的基因表达情况,同时解决用组织样本测序无法解决的细胞异质性难题,让解析单个细胞的行为、机制及其与机体的关系...
单细胞测序(single-cell sequencing)是一种新兴的高通量测序技术,它可以在单个细胞水平上进行基因组、转录组和表观组学的研究。与传统的整体组织测序相比,单细胞测序技术能够更准确地分析细胞的异质性、发现罕见细胞类型和探究细胞发育的分子机制。在单细胞测序中,涉及到的一项重要技术就是空间转录组。 空间转录组(spati...
Sequencing for All Thermo Fisher Scientific Inc. SerialMate Thermo Fisher Scientific Inc. Seristra Thermo Fisher Scientific Inc. SeroMAP Microspheres Luminex Corporation Servalyt Serva Feinbiochemica GmbH and Co. Servin’ Saver Rubbermaid, Inc. SERVING SCIENCE TOGETHER Thermo Fisher Scientific Inc. Sevad...
Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer's Disease PMID: 34447367 | IF=7.561 | Front Immunol. 2021 Aug 9 1、关于文章 文献思路:作者对来自AD病人与Normal对照的外周血取样,同时进行单细胞转录组测序与单细胞免疫组库测序,以研究AD病人的外周血免疫微环境的...
单细胞转录测序(Single-cell RNA sequencing,scRNA-seq)是一种高通量的基因表达 分析技术,可以对单个细胞的转录组进行测序和分析。与传统的 RNA 测序技术相比, scRNA-seq 可以更准确地描述细胞的异质性和复杂性,揭示不同细胞类型之间的转录 差异和基因调控网络,有助于深入理解细胞发育、分化、疾病发生和治疗等方面的...
Single-cell genomic, proteomic, andmetabolic studies have attracted increasing attention with the development ofsingle-cell technologies, such as flow cytometry (1⇓–3), single-cell PCR (4,5), single-cell RNA sequencing (6⇓–8), immunofluo...