2.3Activity-Regulated Cytoskeletal Protein (Arc): signaling pathway integration Arc(also known as Arg3.1) was first identified in 1995 as a novel IEG that is rapidly induced in neurons following increased activity (Link et al., 1995; Lyford et al., 1995). Stimulus-inducible transcription ofArc...
The activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is a neuronspecific immediate early gene (IEG) product. The protein regulates synaptic strength through modulation of spine density and morphology, AMPA receptor endocytosis, and as being part of a retrovirus-li...
Immediate early gene activity‐regulated cytoskeletal‐associated protein regulates estradiol‐induced lordosis behavior in female rats A Christensen,P Dewing,P Micevych - 《Journal of Neuroscience Research》 被引量: 3发表: 2014年 Pattern of Fos and Jun expression in the female rat forebrain after sex...
The time course of activity-regulated cytoskeletal (ARC) gene and protein expression in the whisker-barrel circuit using two paradigms of whisker stimulation. Behav Brain Res. 2015;284:249-56. https://doi.org/10.1016/j.bbr.2015.01.032....
The changes in ARHGAP42 and RhoA activities were correlated with changes in RhoA-regulated actin cytoskeletal dynamics and cell motility in mouse embryonic fibroblasts. ARHGAP42 associates with actin stress fibers and focal adhesions, is auto-inhibited by its N-terminal BAR (Bin/amphiphysin/Rvs) ...
As a hub protein, Arc plays different roles in modulating synaptic plasticity. Arc supports the maintenance of long-term potentiation (LTP) by regulating actin cytoskeletal dynamics, while it guides the endocytosis of AMPAR in long-term depression (LTD). Moreover, Arc can self-assemble into caps...
Cellular growth is regulated by a cascade of kinases, among which mitogen activated protein kinase (MAPK) is an integral member of the Ras-mediated pathway... BM Attar,MJ Atten,O Holian - 《Anticancer Research》 被引量: 65发表: 1996年 Cytoskeletal PKC and ERK/MAPK activation in response to...
We describe a Ca 2+ -sensitive protein complex ... G Krapivinsky,I Medina,L Krapivinsky,... - 《Neuron》 被引量: 380发表: 2004年 Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability of the actin binding proteins Hsp27 and ...
Denker SP, Barber DL: Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol. 2002, 159: 1087-1096. 10.1083/jcb.200208050. Article PubMed Central CAS PubMed Google Scholar Tominaga T, Barber DL: Na-H exchange acts downstream of ...
Activity-regulated cytoskeletal-associated protein (Arc) is an effector immediate early gene induced by novelty and involved in consolidation of long-term memory. Since activation of glucocorticoid receptors is a prerequisite for memory consolidation, we therefore aimed to study the effect of acute ...