2.3Activity-Regulated Cytoskeletal Protein (Arc): signaling pathway integration Arc(also known as Arg3.1) was first identified in 1995 as a novel IEG that is rapidly induced in neurons following increased activity (Link et al., 1995; Lyford et al., 1995). Stimulus-inducible transcription ofArc...
Activity-regulated cytoskeletal-associated protein (Arc) in presynaptic terminals and extracellular vesicles in hippocampal synapsesdoi:10.3389/fnmol.2023.1225533EXTRACELLULAR vesiclesSYNAPSESPRESYNAPTIC receptorsNEURAL transmissionHIPPOCAMPUS (Brain)AMPA receptors...
Immediate early gene activity‐regulated cytoskeletal‐associated protein regulates estradiol‐induced lordosis behavior in female rats A Christensen,P Dewing,P Micevych - 《Journal of Neuroscience Research》 被引量: 3发表: 2014年 Pattern of Fos and Jun expression in the female rat forebrain after sex...
The time course of activity-regulated cytoskeletal (ARC) gene and protein expression in the whisker-barrel circuit using two paradigms of whisker stimulation. Behav Brain Res. 2015;284:249-56. https://doi.org/10.1016/j.bbr.2015.01.032....
Conclusions: These results implicate epigenetic control of cytoskeletal protein regulation as a mechanism for opiate- induced morphologic changes. Ongoing studies are exam- ining in more depth the critical functional role of hdac2 and drebrin in the regulation of structural, cellular and behavioral ...
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder caused by mutations in the gene that encodes the cytoskeletal protein dystrophin. Patients affected by DMD experience muscle weakness from early age and progressive muscle loss as they become older1,2 with death usually occurring in ...
Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoi... Cyclin-dependent kinase 5 (Cdk5), a neuronal Cdc2-like kinase, exhibits a variety of functions in neuronal differentiation and neurocytoskeleto...
Cofilin, an F-actin severing protein that is inactivated by phosphorylation, is a downstream target of a pathway regulated by Rac. We show that transient regulation of cofilin by treatment with NMDA is also disrupted in synGAP mutant neurons. Treatment of wild-type neurons with 25 mum NMDA ...
(H5) in the COOH-terminus is slightly destabilized, due to the flexible C-terminal tail10,11. The matrix protein is continuously released in the extracellular space from HIV-1-infected cells12. It has been detected in the plasma13and in tissue specimens, such as brain14, liver15, bone ...
(Fig.5B), confirming that PKCζ is active in untreated cells arrested in serum-free medium. It should be noted that PHE produced a significantly greater decrease in PKCζ activity than myristoylated PSζ, alone or with PHE, pointing to a closely regulated mechanism of PHE-induced PKCζ ...