Shau, H., Huang, A.C.J., Faris, M., Nazarian, R., De Vellis, J., and Chen, W., "Thioredoxin Peroxidase (Natural Killer Enhancing Factor) Regulation of Activator Protein-1 Function in Endothelial Cells", Biochem. Biophys. Res. Comm., 249, (1998) 683-686....
1. Objective To study the effects of tea polyphenols onactivator protein 1and cell cycle of human liver cancer cell. 目的观察茶多酚对人肝癌细胞激活蛋白1(AP-1)及细胞周期的影响。 2) activator protein-1 激活蛋白1 1. Objective:To investigate the function ofactivator protein-1(AP-1) in prolifer...
Mechanistically, we found that cell polarity disruption activates JNK signaling, which in turn upregulateexpression through transcription factor activator protein-1 (AP-1). We identified a consensus AP-1 binding site located in the 2intron of, and confirmed that it is essential for AP-1 induced...
Objective To investigate the expression of transcription factors including nuclear factor-κB(NF-κB) and activator protein-1(AP-1) in vascular endothelial cells(ECs) in different flow fields,and provide experimental evidence for mechanical signal effects on gene regulation pattern of ECs.Methods Cultur...
The Activator Protein 1 (AP‐1) transcription factor subunit Fos‐related antigen 1 (Fra‐1) has been implicated in liver fibrosis. Here we used loss‐of‐function as well as switchable, cell type‐specific, gain‐of‐function alleles for Fra‐1 to investigate the relevance of Fra‐1 ...
This specificity depends critically on the presence of an activator protein 1 (AP1) motif at position −77. Binding of c-jun/c-fos heterodimers to this sequence confers high levels of expression to the reporter constructs in cultured epidermal keratinocytes, while having little effect in HeLa ...
The yeast heme activator protein Hap1 binds to DNA and activates transcription of genes encoding functions required for respiration and for controlling oxidative damage, in response to heme. Hap1 contains a DNA-binding domain with a C6 zinc cluster motif, a coiled-coil dimerization element, typical...
Ixodes scapularis ticks transmit several pathogens to humans including rickettsial bacterium, Anaplasma phagocytophilum. Here, we report that A. phagocytophilum uses tick transcriptional activator protein-1 (AP-1) as a molecular switch in the regulation
Conclusion We propose that NCU-G1 is a dual-function protein capable of functioning as a transcription factor as well as a nuclear receptor co-activator.doi:10.1186/1471-2199-8-106Knut R SteffensenMariam BouzgaFrode SkjeldalCecilie Kasi
Gentamicin treatment of cochlear explants results in increased activating protein-1 activity in the outer hair cells. The main component of the activating protein-1 complexes was found to be the c-Fos protein, which was found only in gentamicin-treated explants and not in controls.13 A recent ...