The proteasome plays an important role in the regulation of a variety of signaling pathways and the degradation of proteins. The proliferation of myeloma cells is dependent on proteasome-regulated signaling pathways, and thus they are susceptible to PIs [118]. PIs can selectively bind to the activ...
What is the term used when the product of a biochemical pathway inhibits the activity of the first enzyme of a pathway? a. feedback inhibition b. activator inhibition c. diffusional regulation d. enzyme activation How do enzymes cat...
Conversely, epigenetic modifications can regulate the enzymes and proteins involved in metabolism. What roles do these modifications play in the development of renal fibrosis? Can CM offer effective interventions in this context? Both of these questions are challenging, and addressing them will be ...
Despite recent major advances in developing effective vaccines against toxoplasmosis, finding new protective vaccination strategies remains a challenging and elusive goal as it is critical to prevent the disease. Over the past few years, various experimental approaches have shown that developing an effectiv...
What are regulatory proteins? What does a DNA-binding protein do? Regulatory proteins bind to What is a DNA-binding protein motif? How does a DNA-binding protein regulate its own expression? What is the function of DNA ligase in genetic engineering? What determines the proteins that DNA will...
Pepsin is a proteolytic enzyme released as a proenzyme pepsinogen by the main cells of the gastric glands. Gastric $HCl$ acts as an activator. Pepsin's optimum pH is $1.8$ , which is quite acidic.Because the carboxylic acid group on the amino acid in the enzyme's active site must be...
C-reactive protein (CRP)[8], interleukin (IL)-6[31], fibrinogen and plasminogen activator inhibitor-1[32] levels are higher in obese patients compared to healthy subjects. Stanton et al[33] have recently found that obese mice, after high fat and high cholesterol diets, express abnormal ...
In most NCL diseases the storage material consists mainly of subunit c of ATP synthase, while in infantile CLN1 and congenital CLN10 diseases the main components of storage material are sphingolipid activator proteins (SAPs) A and D [28], [29]. Examining the possible implications of PPT1 in...
to tight adhesions on the surface of bacteria and inhibiting the adhesion of bacteria to intestinal epithelial cells70. Moreover, Lypd8 expression has been found to be significantly decreased in colon cancer tissues, and the activities of the IL-6/signal transducer and activator of transcription 3...
Uncoupling proteins (UCP) are members of the mitochondrial anion carrier family64, and five UCP homologs have been identified to date. UCP1, the first UCP identified and the most extensively studied member, is predominantly expressed in brown adipose tissue (BAT) and allows an alternative route ...