The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to an MHC class II molecule selected from HLA-DRB1*08:02 ...
T lymphocytes subpopulations in sentinel node, the natural location for the primary immune response against the tumour, have not been investigated yet. Previously, tumour infiltrating T-lymphocytes (TILs) were studied and the majority of reports...
Treatment of helper T (Th) cells with saponins from soy bean and mung bean prevented their activation by inhibiting cell proliferation and cytokine secretion. However, the saponins did not affect the expression of major histocompatibility complex class II (A(b)) and co-stimulatory molecule (CD86)...
Regulatory T Cells The final type of effector cell is the regulatory T cell. Regulatory T cells are tasked with stopping an autoimmune response once the threat has been eliminated. After helper T cells and cytotoxic T cells bind to a pathogen and work together to rid the body of it, they...
RS Kalish,C Morimoto - 《Journal of Clinical Investigation》 被引量: 62发表: 1988年 Effective antigen presentation to helper T cells by human eosinophils Human peripheral blood eosinophils purified from non-allergic donors were pulsed with the antigens house dust mite extract (HDM), Timothy Grass...
et al. Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4+ T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface. Hum. Reprod. 31, 700–711 (2016). Article CAS PubMed Google Scholar Zhang, Y. H. et al. The ...
Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes. We sought to determine whether different stages of coronary artery disease (CAD) are associated with distinct differentiation patterns of activated T cells... H Methe,S Brunner,D Wiegand,... - 《Journal of the ...
T cells are activated by interaction of cell-surface antigen receptors with major histocompatibility complex (MHC) proteins on the surface of other cells. Studies using soluble oligomers of MHC–peptide complexes and other types of receptor cross-linking agents have supported an activation mechanism ...
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell sequencing, spatial transcriptomics, and bul
The importance of major hubs of metabolic regulation (mTOR, and AMPK) in activation and T helper cell differentiation will also be explored. Finally, as a prominent example of how metabolism can be therapeutically exploited, we describe the impact of fatty acid metabolism on T cell differentiation...