The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to an MHC class II molecule selected from HLA-DRB1*08:02 ...
Cells were first gated based on side scatter (SSC-A) and forward scatter (FSC-A) to exclude debris. Single cells were next selected based on FSC-H versus FCH-A parameters. Cells were then gated on cell population CD3+CD4+and CD3+CD8+to detect T cells. CD69, CD71, HLA-DR were analy...
Treatment of helper T (Th) cells with saponins from soy bean and mung bean prevented their activation by inhibiting cell proliferation and cytokine secretion. However, the saponins did not affect the expression of major histocompatibility complex class II (A(b)) and co-stimulatory molecule (CD86)...
T cells, or T lymphocytes, are a critical component of the immune system, with several different types playing unique roles in defending the body. The main types of T cells include helper T cells, cytotoxic T cells, regulatory T cells, and memory T cells, each specialized to recognize and...
RS Kalish,C Morimoto - 《Journal of Clinical Investigation》 被引量: 62发表: 1988年 Effective antigen presentation to helper T cells by human eosinophils Human peripheral blood eosinophils purified from non-allergic donors were pulsed with the antigens house dust mite extract (HDM), Timothy Grass...
Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes. We sought to determine whether different stages of coronary artery disease (CAD) are associated with distinct differentiation patterns of activated T cells... H Methe,S Brunner,D Wiegand,... - 《Journal of the ...
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
Cloning of a Partial cDNA for Rat Interleukin-12 (IL-12) and Analysis of IL-12 Expression In Vivo Experimental models of autoimmunity in the rat may feature selective activation of either the Th1 or Th2 subset of helper T cells. Interleukin-12 (IL-12) i... PW Mathieson,KM Gillespie -...
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell sequencing, spatial transcriptomics, and bul
In this study, we have analyzed the activation behavior using a mathematical model that describes the binding of multivalent ligands to cell-surface receptors. We show that a simple equilibrium binding model accurately describes the activation data for CD4+ T cells treated with MHC–peptide oligomers...