A polypeptide designated H400 and its encoding nucleic acid are provided as markers specific for activated human T cells. Activated T cells are detected immunochemically by monoclonal antibodies specific for H400 or for its immunogenic peptide fragments. Activated T cells are also detected by nucleic ...
Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma... Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, ...
To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3. Un
Telomeres are nucleoprotein complexes at the ends of chromosomes that prevent DNA degradation and genome instability1. The typically 10–15 kb long chromosome termini are composed of long stretches of TTAGGG (t-type) repeat arrays with an increasing number of variants toward proximal, subtelomeric ...
CL647-65060 CD3ε 145-2C11 Armenian Hamster IgG T cell marker CoraLite Plus 405 (399 nm/422 nm) CL405-65104 CD4 GK1.5 Rat IgG2bk T helper cell marker CoraLite 594 (588 nm/604 nm) CL594-65069 CD8a 53-6.7 Rat IgG2ak Cytotoxic T cell marker CoraLite Plus 488 (493 nm/522 nm)...
摘要: Has the search for a marker of activated fibroblasts finally come to an end? - Journal of Molecular and Cellular Cardiology 关键词: Cardiac fibrosis Proto-myofibroblast Myofibroblast Marker Fibroblast activating protein DOI: 10.1016/j.yjmcc.2015.10.005 被引量: 9 年份: 2015 收藏...
Fluorescence-activated cell sorting purification of pancreatic progenitor cells Here we review progress on isolation and characterization of progenitor cells in the pancreas. We discuss advantages and current limitations of experiments... T Sugiyama,SK Kim - 《Diabetes Obesity & Metabolism》 被引量: 23...
Significantly, it has been commonly assumed that T cells in the context of established progressing cancer patients exhibit an exhausted status (termed as “T cell exhaustion”) due to various factors, such as persistent tumor antigen load, inhibitory checkpoint signaling pathways (e.g. PD-1, LAG...
iodide, 4′,6-diamidino-2-phenylindole, or 7-aminoactinomycin D) and negatively select for a mouse-specificcell surface markersuch as H2Kd(MHC class I alloantigen).2Additional purity can be obtained by positively gating for a human-specific marker such asepithelial cell adhesion...
A negative correlation between T-cell activation and MDSC function was also observed in fresh human CRC tissues. Mechanistic studies revealed that autocrine IFN-α/β upregulated TRAIL expression on activated T cells to elicit MDSC apoptosis via the TRAIL–DR5 interaction and acted synergistically ...