A polypeptide designated H400 and its encoding nucleic acid are provided as markers specific for activated human T cells. Activated T cells are detected immunochemically by monoclonal antibodies specific for H400 or for its immunogenic peptide fragments. Activated T cells are also detected by nucleic ...
a large white blood cell, occurring principally in connective tissue and in the bloodstream, that ingests foreign particles and infectious microorganisms by phagocytosis. [< GermanMakrophagen(pl.) (Metchnikoff, 1887), with -phagenrepresentingPhagozytenphagocytes; seemacro-,-phage] ...
Programmed cell death 1 (PD-1) is widely expressed in tumor-infiltrating lymphocytes (TILs) of triple-negative breast cancer (TNBC). As a dominant inhibitory immune checkpoint (ICP) receptor, cell surface PD-1 is well-known to transduce negative signaling of effector T cell activity during cell...
Telomeres are nucleoprotein complexes at the ends of chromosomes that prevent DNA degradation and genome instability1. The typically 10–15 kb long chromosome termini are composed of long stretches of TTAGGG (t-type) repeat arrays with an increasing number of variants toward proximal, subtelomeric...
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Furthermore, curdlan inhibited RANKL-induced nuclear factor of activated T cell cytoplasmic 1 (NFATc1) expression, thereby decreasing osteoclastogenesis-related marker gene expression, including tartrate-resistant acid phosphatase, osteoclast stimulatory transmembrane protein, cathepsin K, and matrix ...
(B) T cells activated by PHA-P/PMA and subsequently cultured in IL-2 were assessed for expression of CD2, a T-cell marker and costimulatory molecule. Surface staining was performed using PE-labeled mAb and was assessed by flow cytometry. The profiles presented show typical experiments DC ...
A negative correlation between T-cell activation and MDSC function was also observed in fresh human CRC tissues. Mechanistic studies revealed that autocrine IFN-α/β upregulated TRAIL expression on activated T cells to elicit MDSC apoptosis via the TRAIL–DR5 interaction and acted synergistically ...
Finally, the nonresponsive state was not accompanied by IL-4 secretion and appeared to be reversible, since T cell reactivity could be restored by short-term culture in the presence of IL-2. These observations suggest that "primed" T cells remain B7-dependent in vitro and are susceptible to...
12. A composition according to claim 2 wherein said cord blood T cells and other mononuclear cell components in cord blood do not react to allo-antigens in adult peripheral blood on other cord bloods.Description: STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This work was partially funded by ...