The NK cells that accumulated in immune deciduas were not proliferating cells since they did not stain for Ki67. Given that uNK cell numbers typically decline after mid-gestation (E11.5), we speculate that newly recruited killer cells come from peripheral blood. This is supported by our observat...
Using an in vivo rat model for T-ALL, Roser leukemia (RL), suppressed NK cell effector functions were observed. NK cells from T-ALL patients had reduced expression of the activating receptors NKp46 and DNAM-1, but not NKG2D. In contrast to T-ALL patients, NKG2D but not NKp46 was ...
Thus, our findings reveal new fundamental aspects of the NKT-NK cell axis that provide important hints for the manipulation of NK cells in clinical settings. 展开 关键词: NK-cell differentiation NK-cell education NKT cells mCMV αGalCerMPEG ...
Background A subset of CD3negCD56negCD16+ Natural Killer (NK) cells is highly expanded during chronic HIV-1 infection. The role of this subset in HIV-1 pathogenesis remains unclear. The lack of NK cell lineage-specific markers has complicated the study of minor NK cell subpopulations. Results...
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses. in the T cell responses and diminished clinical disease seen in mice treated with anti-NK1.1, anti-asialo GM1, and selected Ly49 subtype-depleted mice... R Winkler-Pickett,HA You...
To evaluate the expression of the commonly known NK cell markers such as Ly49 and NK1.1 (not expressed in the H-2k haplotype, syngeneic with BW tumor cells), IL-2 and IL-2/IL-12 LAK were generated from spleens of allogeneic C57BL/6 (H-2b haplotype) and congenic B10.BR (H-2k ...
(iNKT)cellssemi-invariantcellreceptor(TCR),Vα14-Jα18/Vβ8.2-,humans,multipleactivationmarkersCD25,CD69naturalkiller(NK)celllineageLy49(1-4).iNKTcellsrecognizesglycolipidantigenspresentedMHCclassI-relatedproteinCD1dFollowingTCRengagement,iNKTcellscanrapidlymountcellresponsecharacterizedwidevarietycytotoxicity,...
Immune cell-based therapies using natural killer (NK) cells and cytotoxic T cells are under constant scrutiny, with the aim to design an effective and reduced-toxicity therapy, which will benefit patients via improved quality of life and improved prognosis. Four patients with stage IV colon cancer...
AlthoughNK cellsare remarkably similar toT cellsin the expression ofsurfacemarkers, unlike T cells they do not rearrange theTCRgene and thus show noantigen specificity. A progenitor cell that gives rise to T cells, NK cells, and dendritic cells has been identified (Masuda et al., 2005); this...
The NKT-LAK increased expression of CD69, NKG2D and DNAM-1 compared with NKT in PBMCs, although NK-specific markers remained low or absent (Figure 1C). As expected, the T-cell fraction of PBMCs or LAKs exhibited very low positivity for all NK-specific receptors; however, other ...