LIGANDS OF THE NATURAL KILLER (NK) CELL SURFACE MARKER CD27 AND THERAPEUTIC USES THEREOFThe present invention relates to the modulation of Natural Killer (NK) cells in vitro or in vivo through the use of activating or inhibiting ligands of CD27, such as antibodies, for a regulation of the ...
Comments 注释 The cell line is dependent on the presence of recombinant Il-2 and a dose as low as 10 U/mL is sufficient to maintain proliferation; cells will die within 72 hours in the absence of IL-2. NK-92 cells have the following characteristics: surface marker positive for CD2, CD7...
Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan belonging to the glypican family. These proteoglycans play a crucial role in regulating cell growth and differentiation. GPC3 is highly expressed in several types of cancer, most notably hepatocellular carcinoma (HCC) [55,56]. As a...
m157 and Ly49H makes MCMV infection a special case for NK cell memory, leading to the possibility that the memory me- chanism of Ly49H1 NK cells in MCMV model is different from that in the CHS model, and Ly49H was not convincing enough to be a surface marker for memory NK cells....
NK cell percentage or by total cell number (Fig.7f, g). IFN-γ-producing NK cells when stimulated ex vivo were also remarkably reduced, indicating fewer NK cells were activated in the absence of IFN-γ (Fig.7h). The expression level of NK cell degranulation marker CD107a was also ...
Cytotoxic activity of natural killer (NK) cells and cell surface marker expression ofblood (X ')
Indeed, KIR3DL2 can bind CpG-ODNs (TLR9 ligands) at the NK cell surface by its extracellular D0 domain and shuttle CpG-ODNs to endosomes where TLR9 is localized, thus allowing TLR-mediated activation of NK cell function. Notably, similarly to KIR3DL2, also other KIRs carrying the ...
DX5+NKT cells are characterized by expression of the NK cell marker DX5 in the context of CD3. However, little is known about the phenotype and functional capacity of this unique cell population. Therefore, we investigated the expression of several T cell and NK cell markers, as well as ...
to overexpress MR1 on B16F10 cells (B16F10cherryMR1) and compared tumor growth to control B16F10 cells (B16F10cherry). MR1 overexpression resulted in an increase in cell surface MR1 expression, but did not significantly affect the extent of B16F10 metastases either in the presence or absence...
by granzyme M N Baschuk1, N Wang2, SV Watt1, H Halse1, C House1, PI Bird3, R Strugnell2, JA Trapani1,4,5, MJ Smyth1,4,5,6,7,8 and DM Andrews*,1,4,5,8 Granzymes are generally recognized for their capacity to induce various pathways of perforin-dependent target cell death...