Tumor-resident CD8+ T cells display a quiescent effector/memory phenotype that is maintained in part by infiltrating CD4+ CD25+ Foxp3+ T-suppressor cells. Intratumoral delivery of IL-12, in contrast, can restore cytotoxic function to tumor-associated CD8+ T cells and induce the apoptotic death...
Growth of subcutaneous CMS5a tumours (1.0–1.2 cm tumour diameter) was significantly attenuated in DUC18 CD8 EV- and BALB CD8 EV-treated groups by i.t. administration compared to BALB CD4 EV (from CD8+cell-depleted BALB/c splenocytes)-, CMS5a EV- or hPBMC EV-treated groups (Sup...
Finally, in synovial fluid we found accumulation of CXCR3CD8T cells and CD69cells. CD4T cells in the two compartments shared many similarities with CD8T cells. The results indicate a role for memory T cell effectors in systemic and joint manifestations of psoriatic arthritis....
Tumor-resident CD8+ T cells display a quiescent effector/memory phenotype that is maintained in part by infiltrating CD4+ CD25+ Foxp3+ T-suppressor cells. Intratumoral delivery of IL-12, in contrast, can restore cytotoxic function to tumor-associated CD8+ T cells and induce the apoptotic death...
Our results suggest that there is a dysregulation in T-cell homeostasis in aged mice associated with a decrease in AICD of CD8 + T cells. 展开 关键词: Aging CD8 + T Cells Activation-induced cell death Apoptosis Fas Fas ligand IFN-γ ...
Ectopic T-bet expression by OT-I CD8+ T cells stimulated by the H2-Kb (SIINFEKL) complex and cultured with 2ng/mL IL-2 induced a coordinated change in gene expression leading to down-regulation of CD127 and SOCS-1 and up-regulation of CD122 and IL-15 receptor , switching the ...
We found that CD8 memory cells could acquire bystander-activated, cytotoxic CD8 T cell (BA-CTL) function without the involvement of a strong, agonist TCR signal. Brief exposure to IL-12, IL-15, and IL-18 acting directly on the T cells was sufficient to induce cytotoxic potential. Given ...
Here, we examined the impact of the microbiota on CD8+ T cell memory. Antigen-activated CD8+ T cells transferred into germ-free mice failed to transition into long-lived memory cells and had transcriptional impairments in core genes associated with oxidative metabolism. The microbiota-derived short...
Activated CD8(+) T cells and NKT cells in BAL fluid improve diagnostic accuracy in sarcoidosis. A, Ro AD, Asberg A, Borset M, Moen T, Sue-Chu M: Activated CD8 T cells and NKT cells in BAL fluid improve diagnostic accuracy in sarcoidosis. ... A T?Ndell,AD R?,?sberg, A.,......
Transmigration-associated molecules such as selectins, integrins, and chemokines and their receptors expressed by hepatic vessels and recruited T-cells were analyzed by immunohistochemistry and flow cytometry. The immunoelectron microscopic analysis clearly showed CD8β+cells passing through the portal vein ...