Our results suggest that there is a dysregulation in T-cell homeostasis in aged mice associated with a decrease in AICD of CD8 + T cells. 展开 关键词: Aging CD8 + T Cells Activation-induced cell death Apoptosis Fas Fas ligand IFN-γ ...
To confirm the anti-mesenchymal stromal nature of CD8+T cell-derived EVs in vivo, MSCs were cultured from crushed femur bones of Thy-1.1+BALB/c congenic mice (Supplementary Fig.8a–c), and Thy-1.1+MSC-chimeric BALB/c mice were prepared by transferring cultured Thy-1.1+MSCs into irradiated ...
1) activated T cell 活化T细胞 1. Objective:To observe the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF)on peripheral active signal of T cell surface antigen(CD4+CD28+,CD8+CD28+),activated T cells,and regulatory T cells during mobilization of hematopoietic stem cells ...
mass cytometry CD8 T cell immunometabolism T cell activation Introduction Understanding the regulatory mechanisms underlying immune responses is crucial to developing more rationally designed treatment strategies for acute and chronic infections, autoimmune diseases, and malignancy (Buck et al., 2017). CD8+...
HIV-1 infection is characterized by chronic immune inflammation, aberrantly heightened CD8(+) T cell activation levels, and altered T cell function. The relationship between MAPK pathway function, HIV-1-induced activation (CD38 and HLA-DR), and exhaustion (Tim-3) markers in circulating CD8(+) ...
Immune recognition is induced by HLA-I presentation of peptides derived from incoming viral particles, and recognition occurred either following cell-free virus infection or following cell-to-cell spread. CD8+ T cells from HIV controllers mediate more effective immune recognition than CD8+ T cells ...
Defective Cytokine Expression but Adult-Type T-cell Receptor, CD8, and p561ckModulation in CD3- or CD2-Activated T Cells from Neonates H. PIRENNE-ANSART, F. PAILLARD, D. DE GROOTE, A. ELJAAFARI, S. LE GAC, P. BLOT, P. FRANCHIMONT, C. VAQUERO, AND G. STERKERS Laboratoire du De...
and CD8 þ T-cell immune responses in surviving mice as indicated by T-cellemediated, antigen-specific proliferation and direct killing of tumor cells ex vivo. In addition, the therapeutic protocol restores the ability of DCs to directly kill DL cells, which was observed in untreated mice....
The immunoelectron microscopic analysis clearly showed CD8β+cells passing through the portal vein (PV) endothelia. Furthermore, the migrating pathway seemed to pass through the endothelial cell body. Local vascular cell adhesion molecule-1 (VCAM-1) expression was induced in PV endothelial cells from...
T cell function and activated CD8+38+45RO+ T cells as progression markers in hemophiliacs with long term HIV infectionHIV-related bone marrow changes are consistent with myelodysplastic features (MDF). Their pathogenesis may differ from ... Z Poulopoulou,C Psarra,V Kapsimali,... - 《Immunol...