Activated CD4+ T Cells impact adipose-serived stromal cell function through CD40-dependant activation - ScienceDirectBackground & Aim Although native bone marrow-derived mesenchymal stromal cells (BM-MSC) have been described to express CD40, how CD40 is regulated on MSC, and whether CD40 signaling...
Thus, the regulatory role of activated CD4+Foxp3− T cells in NK-cell activity must be taken into consideration in the future design of cancer therapies. Keywords: NK cells; T cells; suppression; melanoma; metastasis; Qa-1 Cell Research (2012) 22:1696-1706. doi:10.1038/cr.2012.128; ...
CD4+ T cells were activated with anti-CD3 and anti-CD28 mAbs. Hela cells were presensitized with aCD4 or conditioned supernatant (aCD4S) or recombinant cytokines for 2 days, followed γ-irradiation. The treated cells were cultured for an additional 2 to 5 days for cell proliferation, cell ...
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4+ T cells are necessary for lymphedema pathogenesis by utilizing adopt
Cell-to-cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 response. The production of IL-12 by monocytes and dendritic cells is tightly regulated and critically dependent on signals from surrounding cells in the micromilieu... M Wittmann,M Alter,T Stü...
Cell-to- cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 response. J Allergy Clin Immunol 2004;114:965-73.Wittmann M,Alter M,Stunkel T, et al.Cell-to-cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 ...
In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Ant... Matsuyama,T. - 《Journal of Experimental Medicine》 被引...
NK cell killing of activated CD4+ T cells was suppressed by HLA-E on CD4+ T cells, as blocking the interaction between HLA-E and the inhibitory CD94/NKG2A NK cell receptor enhanced NK cell degranulation. This study provides new insight into CD56dim and CD56bright NK cell-mediated ...
29 We found, for the first time, that the CD4+ T cell can be activated during hemarthrosis. Studies have widely explored that abnormal CD4+ T cell activation, mainly including Th1 and Th17 cells, can contribute to liver inflammation and other diseases.21 Our findings are consistent with ...
Assessment of T cell activation has traditionally been performed by measuring proliferation as a function of 3[H]-thymidine incorporation, or secretion of ... BA Mehta - 《Journal of Immunological Methods》 被引量: 253发表: 1997年 Early appearance of activated CD4+ T lymphocytes and class II ...