Thus, NK cells normally patrol throughout your body, acting almost like tiny but well-armed security guards. As they circulate in your bloodstream, NK cells constantly seek out cells that lack the proper “ID badge,” in the form of molecular patterns indicating that they are authorized parts...
In this study, we demonstrate that IMiDs also directly bind and activate zeta-chain-associated protein kinase-70 (Zap-70) via its tyrosine residue phosphorylation in T cells. IMiDs also triggered phosphorylation of Zap-70 in natural killer (NK) cells. Importantly, increased granzyme-B (GZM-B)...
Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature. 1994; 372 :150–157. doi: 10.1038/372150a0. [ Cross Ref ]KAREL BEZOUSKA ET AL.: " Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity ", NATURE, vol. 372, 10 November 1994 (...
CML-RAE-1γ-Dex effectively enhanced the proliferation and effector functions of NK cells, CD4+ T cells and CD8+ T cells, which in turn produced strong anti-CML efficacy in vitro. Moreover, CML-RAE-1γ-Dex-based immunotherapy inhibited leukemogenesis and generated durable immunological memory ...
Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro... G Manukyan,A Martirosyan,L Slavik,... - Auto-Immunity Highlights 被引量: 0发表: 2020年 Regulation of vascular endothelial growth factor production and an...
ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis. J. Immunol. 182: 3398-3405... ...
Here, we found that in vivo natural killer (NK) cell killing of tumor cells, but not of normal cells, depends on STING expression in non-tumor cells. Experiments using transplantable tumor models in STING- and cGAS-deficient mice revealed that cGAS expression by tumor cells was critical for ...
a5-AZA-CdR reduces natural killer cell responsiveness, which may be used in therapeutic strategies to target malignant cells by an immune mechanism 5 AZA司令官减少NK细胞快速响应,也许用于治疗战略瞄准恶性细胞由一个免疫机制[translate] aplease send us your best firm offer by fax indicaing packing spe...
as shown in Fig.1. The bacterial molecules stimulate multiple pattern recognition receptors, leading to the extensive release of immune-promoting cytokines and activation of effector lymphatic cells, including T cells and natural killer (NK) cells; the gold nanoparticle inner core, with intrinsic phot...
Chimeric antigen receptor (CAR)-T cells represent a major breakthrough in cancer therapy, wherein a patient’s own T cells are engineered to recognize a tumor antigen, resulting in activation of a local cytotoxic immune response. However, CAR-T cell therapies are currently limited to the treatm...