This agent is a DNA-intercalating compound that inhibits both DNA and RNA synthesis. Its major mechanism of action is thought to be through the generation of DNA strand breaks via interaction with topoisomerase II. Dactinomycin is indicated in the treatment of patients with Wilm's tumor, ...
Actinomycin D: An Effect on Rat Liver Homogenates Unrelated to Its Action on RNA Synthesis 来自 NCBI 喜欢 0 阅读量: 28 作者:M Revel,HH Hiatt,JP Revel 摘要: Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino ...
摘要: Actinomycin-D produces hypocalcemia in rats 10 to 15 hours after administration. This effect can be produced in the absence of kidneys, adrenals and thyroid glands. Possible mechanisms of action are discussed.DOI: 10.3181/00379727-119-30343 被引量: 6 年份: 1965 ...
The failure of lung cancer treatments has been attributed mostly to the development of drug resistance, however the underlying cellular and molecular mechanisms are poorly understood. Cancer initiating stem cells (CSCs), present in tumors in a small percentage, play critical roles in the development ...
Actinomycin D (dactinomycin, Cosmogen®) is a natural chromopeptide composed of a heterocyclic chromophore and two cyclic pentapeptide lactone rings. The heterocyclic fragment is a phenoxazine derivative, containing a quinonimine portion, and is responsible for the color of the compound and its inter...
actinomycins, X2and D, while the penicillin-binding protein-1a, was the least-favorable target-protein. In conclusion,Streptomyces smyrnaeusUKAQ_23 emerged as a promising source of Actinomycin X2with the potential to be scaled up for industrial production, which could benefit the pharmaceutical ...
ACTINOMYCIN-D TREATMENT IN A CASE OF ACUTE INTERMITTENT PORPHYRIA G Yuill - 《Lancet》 被引量: 9发表: 1970年 Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms 1. The ...
www.nature.com/scientificreports OPEN Human p53 interacts with the elongating RNAPII complex and is required for the release received: 24 June 2016 accepted: 14 December 2016 Published: 19 January 2017 of actinomycin D induced transcription blockage Barbara N. Borsos1, Ildikó Huliák1, ...
Also cell surface hydrophobicities of S. epidermidis were assessed to explore action mechanisms. The qPCR was performed to demonstrate the genetic mechanisms of biofilm formation by S. epidermidis . Unlike other antibiotics, actinomycin D (1·5 μ g ml1) from Streptomyces luteus significantly ...
Because of the complexity of actinomycin action, several mechanisms can be proposed to explain its effect on nuclear ER levels.doi:10.1016/0020-711X(78)90073-3K B HorwitzW L McGuireJournal of Biological Chemistry