This cytotoxic action is the basis for their use in the treatment of certain types of cancer. Dactinomycin is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis. Mechanism of action Good evidence exists that this drug bind strongly, but reversibly, to DNA, ...
161 – MECHANISM OF ACTION OF ACTINOMYCIN D IN THERAPEUTIC CONCENTRATIONSdoi:10.1016/B978-0-08-021308-8.50182-4T. J. LindellA. O'MalleyAbstracts
Its mechanism of action is through DNA intercalation and inhibition of RNA and protein synthesis, and it is cell cycle phase nonspecific. After IV administration, the drug concentrates in nucleated cells; it does not penetrate the blood-brain barrier, and it is minimally metabolized. Excretion ...
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number...
The isolation of actinomycin in 1940 earned the Nobel Prize for Selman Waksman. Studies of the mechanism of action of this antibiotic showed that it acted by binding to double-stranded DNA and stopping the transcription of this DNA into RNA. By being bound in this manner, actinomycin inhibited...
Injection of excess parathyroid hormone did not alter this result; this eliminates the possibility that the inhibition of vitamin action was due to blocked hormone synthesis. As a result of these findings, a hypothesis concerning the mechanism of action of vitamin D is presented.关键词:...
Mechanism of action Dactinomycin is cleared rapidly from plasma, does not enter the brain, is not appreciably metabolized or protein bound, and is gradually excreted in both bile and urine.Virtually no drug is detected in CSF. Clinical Use Dactinomycin is used in curative combined treatment of ...
Antibacterial and mechanism of action studies of boxazomycin A Article 01 August 2024 Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies Article Open access 30 December 2024 The Antibiotic Peptide Daptomycin ...
It is proposed that the toxin's mechanism of action on ribosomal ... EH Harley,KR Rees - 《Biochemical Journal》 被引量: 63发表: 1969年 A mechanism for the action of pregnant mare serum gonadotropin on aromatase activity in the ovarian follicle of the medaka, Oryzias latipes Our recent ...
Based on findings from animal studies and its mechanism of action, COSMEGEN can cause fetal harm when administered to a pregnant woman [seeCLINICAL PHARMACOLOGY]. In animal reproduction studies, administration of dactinomycin to pregnant animals during the period of organogenesis was teratogenic, result...