Actinomycin and DNA transcription. Herein, using actinomycin D (ACTD) as a model, we have attempted to elucidate the effects of spermine on the action of ACTD, including its DNA-binding ability, RNA and DNA polymerase interference, and its role in the transcription ... HM Sobell - 《Proceedi...
EMSA analysis confirmed the authenticity of CREB and Sp1 binding sites. The transcriptional start site was identified to be an adenine residue at position -55 in the mouse PDE4A10 promoter. We present evidence that this novel down-regulation of PDE4A10 is mediated by the transcription factor ...
Actinomycin and DNA transcriptionActinomycin and Nucleic Acid FunctionACTION OF ACTINOMYCIN DON ANIMAL CELLS AND VIRUSEStudies of the binding of actinomycin and related compounds to DNABasis of actinomycin action. I. DNA binding and inhibition of RNA-polymerase synthetic reactions by actinomycin.DNA struct...
Sobell HM: Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. [Article] Turan T, Karacay O, Tulunay G, Boran N, Koc S, Bozok S, Kose MF: Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in...
Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. [2] Ulrich Hollstein. Actinomycin. Chemistry and mechanism of action. Chem. Rev., 1974, 74 (6), pp 625–652 分子式 C62H86N12O16 分子量1255.42 CAS号50-76-0 储存方式﹣20 ℃冷藏长期储存。冰袋...
作用靶点:DNA/RNA Synthesis|Autophagy|Bacterial|Apoptosis|Antibiotic 结构分类:生物碱|结构分类 In Vitro:Actinomycin D (Dactinomycin) is an inhibitor of DNA transcription and replication. Actinomycin D markedly reduces the vascular smooth muscle cells (SMC) proliferation via the inhibition of BrdU incorpora...
1. 1. The effect of an inhibition of RNA and protein syntheses on DNA synthesis was studied using actinomycin D and cycloheximide in synchronously growing populations of HeLa cells. Following the exposure of cells to the drugs, a distinction was made between the cells that were synthesizing DNA...
In Vitro: Actinomycin D is an inhibitor of DNA transcription and replication [1]. Actinomycin D markedly reduces the vascular smooth muscle cells (SMC) proliferation via the inhibition of BrdU incorporation at 80 nM. This is further supported by the G1-phase arrest using a flowcytometric ...
Borisovaet al.(1968)showed in experimentsin vitrothat theantibioticactinomycin Dquenched the fluorescence of AO bound to pure DNA and DNA in chromatin. A method for the estimation of the length of chromatin DNA regions not accessible to ligands was proposed. Approximately half of the DNA in nati...