Actin remodeling contributing to cell migration is a coordinated process involving the severing of existing filaments to generate new barbed ends, the action of actin capping proteins to restrict polymerization, the branching mediated by Arp2/3, and the bundling and cross-linking of actin filaments....
Actin Remodeling in Motile Cells Actin Remodeling in Motile CellsOsborn, By Eric A
It has been implicated in the formation and dissociation of complexes between actin and actin binding proteins, supporting its role in actin remodeling. Several studies point towards its ability to facilitate formation of special cellular structures including focal adhesions and actin stress fibres by ...
Chollet C, Bareille R, Remy M, Guignandon A, Bordenave L, Laroche G, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci 2012;12(12):1648e59.Chollet, C., et al., Impact of peptide micropatterning on ...
Here we investigate the role of the Actin cytoskeleton in the formation of the Drosophila compound eye, which requires extensive remodeling and coordination between different cell types. We show that CYFIP/Sra-1, a member of the WAVE/SCAR complex and regulator of Actin remodeling, controls ...
Actin remodeling is the result of activation of oncogenic actin signaling pathways (e.g., Ras and Src), or inactivation of several important actin-binding proteins that have tumor suppressor functions (e.g., gelsolin). Distinctive protein expression patterns of some of these genes in cancer and...
Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin 尾1 cycling and actin remodeling. Proc Natl Acad Sci U S... L Gewei,L Jie,H Jianjun,... - 《Bioarchitecture》 被引量: 43发表: 2014年 Purification and Cloning of a Brefeldin A-inhibited Guanin...
Effective phagocytosis is crucial for host defense against pathogens. Macrophages entrap pathogens into a phagosome and subsequently acidic lysosomes fuse to the phagosome. Previous studies showed the pivotal role of actin-remodeling mediated by phosphoi
Yang, N. et al. Effects of dexamethasone on remodeling of the hippocampal synaptic filamentous actin cytoskeleton in a model of pilocarpine-induced status epilepticus. Int. J. Med. Sci. 17, 1683–1691 (2020). Gupta, R., Kumar, G., Jain, B. P., Chandra, S. & Goswami, S. K. Ectop...
In the present study, we demonstrate that changes in adipocyte size correlate with a drastic remodeling of the actin cytoskeleton. Expansion of primary adipocytes following 2 weeks of high-fat diet (HFD)-feeding in C57BL6/J mice was associated with a drastic increase in filamentous (F)-actin ...