Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?doi:10.3389/fimmu.2023.1276602CYTOSKELETONCANCER cellsKILLER cellsCYTOTOXIC T cellsDENDRITIC spinesSYNAPSESCytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and na...
Actin Cytoskeleton Remodeling by the Alternatively SplicedIsoform of PDLIM4/RIL Protein *Receivedforpublication,March21,2011,andinrevisedform,May19,2011 Published,JBCPapersinPress,June2,2011,DOI10.1074/jbc.M111.241554Olga A. Guryanova ‡§ , Judith A. Drazba ‡ , Elena I. Frolova § , and...
The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon (IFN) responses. Here, we report that actin cytoskeleton disturbance primes RIG-I-like receptor (RLR) activation. Ac...
We now report fast and profound remodeling of the actin cytoskeleton across different domains of dorsal root ganglion (DRG) axons during degenerationin vitroinduced by trophic factor withdrawal (TFW), including early and massive growth cone collapse (GCC). The MPS shows a significant decrease in ab...
It is thus reasonable to conclude that actin remodeling mediated by the coordinated actions of Rac signaling and MyoII leads to the translocation of KATP channel-containing vesicles to the plasma membrane. In pancreatic β-cells, the role of the cytoskeleton in regulating vesicle trafficking has ...
Cytoskeleton remodeling The actin-binding protein, cortactin, has been reported to control the number of MVBs moving toward cortical actin and to increase the number of PM-docking sites by stabilizing branched-actin structures [73]. Stable branched-actin networks eventually facilitate the transfer of ...
However, lupeol did not affect the motility of other cancer cells. The results suggest that lupeol suppresses the migration of malignant melanoma cells by disassembling the actin cytoskeleton. 展开 关键词: B16 2F2 cell differentiation cofilin dendritic outgrowth lupeol stress fiber MAPK, mitogen-...
This investigation will focus on the effect of microgravity on the alpha-actin, beta-actin, and myosin components of the cytoskeleton in resting and contracting A7r5 smooth muscle cells. We have provided evidence of differential remodeling... KM Whitenack,C Arnold,D Gibson,... - 《Faseb Journal...
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The ATPase activity of actin is strongly coupled to the dynamics of the actin cytoskeleton. The inherent nucleotide-dependent dynamics of actin can be influenced by different actin-binding proteins (ABPs), which can tune the nucleotide-dependent remodeling of the actin cytoskeleton with high ...