Given the role HtsRC may be playing in the crucial remodeling and organization of the RC actin cytoskeleton during development, we are now interested in identifying its binding partners. To this end, we fused HtsRC to the APEX enzyme to achieve proximity‐dependent biotinylation of HtsRC‐...
Cytoskeleton remodeling The actin-binding protein, cortactin, has been reported to control the number of MVBs moving toward cortical actin and to increase the number of PM-docking sites by stabilizing branched-actin structures [73]. Stable branched-actin networks eventually facilitate the transfer of ...
Actin Cytoskeleton Remodeling by the Alternatively SplicedIsoform of PDLIM4/RIL Protein *Receivedforpublication,March21,2011,andinrevisedform,May19,2011 Published,JBCPapersinPress,June2,2011,DOI10.1074/jbc.M111.241554Olga A. Guryanova ‡§ , Judith A. Drazba ‡ , Elena I. Frolova § , and...
The ATPase activity of actin is strongly coupled to the dynamics of the actin cytoskeleton. The inherent nucleotide-dependent dynamics of actin can be influenced by different actin-binding proteins (ABPs), which can tune the nucleotide-dependent remodeling of the actin cytoskeleton with high ...
In the early stages of spine formation, the interplay between the elastic properties of the spine membrane and the protrusive forces generated in the actin cytoskeleton propels the incipient spine. In the maturation stage, actin remodeling in the form of the combined dynamics of branched and ...
Lysophosphatidic acid (LPA) is a multifunctional regulator of actin cytoskeleton that exerts a dramatic impact on the actin cytoskeleton to build a platform for diverse cellular processes including growth cone guidance, neurite retraction and cell motility. It has been implicated in the formation and ...
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Yang, N. et al. Effects of dexamethasone on remodeling of the hippocampal synaptic filamentous actin cytoskeleton in a model of pilocarpine-induced status epilepticus. Int. J. Med. Sci. 17, 1683–1691 (2020). Gupta, R., Kumar, G., Jain, B. P., Chandra, S. & Goswami, S. K. Ectop...
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the rece...
Dynamic remodeling of the actin cytoskeleton is essential for many cellular processes. Tracking the movement of individual actin filaments can in principle shed light on how this complex behavior arises at the molecular level. However, the information that can be extracted from these measurements is ...