Smooth muscle 伪 actin (Acta2) expression is largely restricted to smooth muscle cells, pericytes and specialized fibroblasts, known as myofibroblasts. Liver injury, associated with cirrhosis, induces transformation of resident hepatic stellate cells into liver specific myofibroblasts, also known as ...
Smooth muscle 伪 actin (Acta2) expression is largely restricted to smooth muscle cells, pericytes and specialized fibroblasts, known as myofibroblasts. Liv... Rockey,C Don,Weymouth,... - 《Plos One》 被引量: 31发表: 2013年 Lipocalin-2 elicited by advanced glycation end-products promotes the ...
Öhlund, D.; Handly-Santana, A.; Biffi, G.; Elyada, E.; Almeida, A.S.; Ponz-Sarvise, M.; Corbo, V.; Oni, T.E.; Hearn, S.A.; Lee, E.J.; et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.J. Exp. Med.2017,214, 579–596. [...
Properties and functions of fibroblasts and myofibroblasts in myocardial infarction. Cells. 2022;11:1386. Article CAS PubMed PubMed Central Google Scholar Xu L, Sharkey D, Cantley LG. Tubular GMCSF promotes late MCP-1/CCR2-mediated fibrosis and inflammation after ischemia/reperfusion injury. J ...
Vascular pathology and analysis of explanted SMCs and myofibroblasts from patients harboring ACTA2 suggested that increased proliferation of SMCs contributed to occlusive diseases. These results indicate that heterozygous ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases...
In addition to fibroblasts, SMC/myofibroblasts and mesothelial cells, we identified 2 distinct pericyte clusters both expressing canonical pericyte markers such asPdgfrbandCsgp4(Ng2) and differentiated by presence or absence ofActa2.Acta2+pericytes exhibited high expression of contractile markers (i.e....
结论 肝癌HepG2细胞系分泌的Exosome可诱导脂肪组织来源的MSC分化为CAF,后者又可以促进HepG2细胞的增殖,迁移和侵袭.%Objective To investigate the effect of human hepatocellular carcinoma HepG2 cell-derived Exosome on the differentiation of mesenchymal stem cells(MSC)into cancer-associated myofibroblasts(CAF...