摘要 Mycobacterium tuberculosis (Mtb) primarily infects macrophages. In vitro without antibiotics, wild-type Mtb hastens death of the macrophages, but the processes leading to rapid cell death are not well understood. Our earlier work indicated that the death of Mtb-infected mouse macrophages in vit...
摘要 The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is essentially affecting their capacity of combating tumor cells. Here we find, via a pooled metabolic gene knockout CRISPR screen thatKEAP1andACOD1are strong regulators of the pro-inflammatory state in macroph...
via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 are strong regulators of the pro-inflammatory state in macrophages. We show that ACOD1 knockout macrophages, generated in our induced pluripotent stem cell-derived CAR-macrophage (CAR-iMAC) platform, are strongl...
Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J. Immunol. 174, 595–599 (2005). CAS PubMed Google Scholar Hanada, T. & Yoshimura, A. Regulation of cytokine signaling and inflammation. ...
ACOD1 knockdown significantly inhibited SA-induced macrophage inflammatory response, attenuated SA-induced nuclear envelope wrinkling, and plasma membrane rupture, and suppressed the TLR4/NF-魏B signaling pathway. Furthermore, ACOD1 knockdown reduced the inflammatory response and alleviated lung tissue ...
ACOD1 in immunometabolism and disease. 2.West AP, et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. 3.Shi HZ, et al. Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Pan J, et al. MicroRNA-378 acts ...
Here we find, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 are strong regulators of the pro-inflammatory state in macrophages. We show that ACOD1 knockout macrophages, generated in our induced pluripotent stem cell-derived CAR-macrophage (CAR-iMAC) platform, are ...
As mentioned previously, the majority of studies on ITA have been conducted on cells of the monocyte-macrophage lineage, and we were therefore surprised by its detection in prostate cancer cells.41,42,43 We next sought to investigate if the changes in ITA in PRp cells are associated with chan...
the mitochondrial enzyme aconitate decarboxylase 1 (ACOD1, best known as immunoresponsive gene 1 [IRG1]) is upregulated under various inflammatory conditions and serves as a pivotal regulator of immunometabolism involved in itaconate production, macrophage polarization, inflammasome activation, and oxidati...
In particular, the mitochondrial enzyme aconitate decarboxylase 1 (ACOD1, best known as immunoresponsive gene 1 [IRG1]) is upregulated under various inflammatory conditions and serves as a pivotal regulator of immunometabolism involved in itaconate production, macrophage polarization, inflammasome ...