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Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion channels. AChRs are expressed by neurons ...
Figure 1. The structure of acetylcholine. For a cholinergic neuron to receive another impulse, acetylcholine must be released from the receptor to which it has bound. This will only happen if the concentration of acetylcholine in the synaptic cleft is very low. Low synaptic concentrations of ...
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The structure, function, and physiology of the fetal and adult acetylcholine receptor in muscle. Front. Mol. Neurosci. 13, 581097 (2020). CAS PubMed PubMed Central Google Scholar Rimer, M., Mathiesen, I., Lømo, T. & McMahan, U. J. γ-AChR/ε-AChR switch at agrin-induced ...
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(N2) is composed of 2α and 3β subunits. Upon binding 2 acetylcholine molecules to the nicotinic acetylcholine receptor, the pentameric structure will change its internal conformation, creating a transmembrane pore for the passage of sodium, potassium, and calcium ions. The passage of these ions...
Structure, function and pathogenicity. Lazaridis K, Sideri A, Zouridakis M, and Tzartos SJ (2007) Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity. ... D Kalamida,K Poulas,V Avramopoulou,... - 《Febs Journal》 被引量: 344发表: 2010年 Neuronal...
The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution structure of a protein that is homologous to the extracel