For cele- and mavacoxib, sample preparation consisted of sequential addition of 25 µL of IS WS (1000 ng/mL celecoxib-D7, 200 ng/mL mavacoxib-D4), 25 µL of ethanol, 150 µL of 0.1 M NaOH and 3 mL of ethyl acetate to 50 μL of plasma. After vortex mixin...
The identification of novel pan-sigma receptor (SR) modulators, potentially useful in cancer treatment, represents a new goal of our research. Here, we report on the preparation of novel chiral compounds characterized by a 3-C alkyl chain bridging an aromatic portion to a 4-benzyl-piperidine mo...
5-dimethylphenylcarbamate amylose coated onto aminopropylsilyl Nucleosyl (500 Å, 7 µm, 20%,w/w) [52], based on a previous work [27]. After optimization of the chromatographic conditions, a mixture of hexane:ethanol:diethylamine (Hex:EtOH:DEA, 97:3:0.1v/v/v) as the mobile phase ...