Aberrant glycosylations as biomarkers of autoimmune diseases correlating with disease activity: toward the development of reliable diagnostic/prognostic toolsPapini, A M
Using IgA1-producing cell lines, we have analyzed the heterogeneity of IgA1 O -glycosylation and the corresponding biosynthetic pathways. IgA1 secreted by cells from IgAN patients vs. healthy controls had more O -glycans and more galactose-deficient sites. These changes were associated with ...
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. Cell Mol Life Sci 2013; 70: 829-839.M. Stuchlova Horynova, M. Raska, H. Clausen, J. Novak, Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA ...
P.J. Delves The role of glycosylation in autoimmune disease Autoimmunity, 27 (1998), pp. 239-253 CrossrefView in ScopusGoogle Scholar Domon and Costello, 1988 B. Domon, C.E. Costello A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates Glycoconj. J...
Glycosylation is among the most important post-translational modifications for proteins and is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50%–70% of proteins in circulation are glycosylated, and the “sweet attachments” have versatile structural and functional ...
Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, the mechanisms of B7H3 glycosylation reg
Altered glycosylation might indicate various diseases, including cancer, autoimmune diseases and congenital defects of glycosylation [1], [2]. Since carbohydrates are frequently involved in many biological processes (e.g. cell-cell recognition, cell-matrix, host-pathogen interaction, immune modulation, ...
In multiple myeloma (MM), aberrant auto-and/or ... KA Kocemba,RWJ Groen,VA Harmen,... - 《Plos One》 被引量: 75发表: 2012年 Endothelial Expression of MHC Class II Molecules in Autoimmune Disease. The MHC class II subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses...
Human serum immunoglobulin A1 (IgA1) has a unique mucine-like structure in its hinge region that contains O-glycans and proline-rich peptides. We previously reported the under-O-glycosylation of the hinge in serum IgA1 and deposited IgA1... A Horie,Y Hiki,H Odani,... - 《American Jo...
IgA nephropathy (IgAN), a frequent cause of end-stage renal disease, is an autoimmune disease wherein immune complexes consisting of IgA1 with galactose-deficient O-glycans (Gd-IgA1; autoantigen) and anti-glycan autoantibodies deposit in the glomeruli and induce renal injury. Serum IgA1 has ...