In viability assays of many different combinations of BCR pathway inhibitors in ABC DLBCL cell lines, we observed differential combination growth inhibition effects that suggest general principles required for rational combination treatment design. Namely, inhibition of lateral pathways within a signaling ...
The MALT1B phospho-mutant S559/562A and S645/649A did not significantly affect cell growth of ABC-DLBCL cells. However, the MALT1 S803/805A mutant, as well as the combined MALT1 6xS/A, significantly impaired the ability of MALT1 to rescue growth of the three ABC-DLBCL cell lines (...
Interestingly, 2 other ABC-DLBCL cell lines, OCI-Ly3 and HBL-1, in which the NF-魏B pathway is activated by a mutation in CARD11 which is downstream of BTK, are not inhibited by PCI-32765. Both sensitive and resistant cells express Btk at similar levels, and th...
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT) Background The glycosylphosphatidylinositol (GPI)-anchored epithelial extracellular membrane serine protease prostasin (PRSS8) is expressed abundantly in n... LM Che...
MALT1 E549 is required for survival of ABC DLBCL cell lines.Katrin, CabalzarChristiane, PelzerAnnette, WolfGeorg, LenzJustyna, IwaszkiewiczVincent, ZoeteStephan, HailfingerMargot, Thome
Gain and loss of function assays of a subset of these genes in ABC and GCB DLBCL cell lines show that they have tumor suppressor functionsdoi:10.1182/blood.V114.22.619.619Rita ShaknovichHuimin GengNathalie JohnsonLeandro CerchiettiAri Melnick...
Methods: IRAK4 in human PBMC, ABC DLBCL cell lines and tumor xenografts was quantified by immunoassays or targeted mass spectrometry. Cell viability and cell cycle were monitored by flow cytometry. Tumor xenograft studies were conducted by implanting human ABC DLBCL lines into immunocompromised mouse ...
We have recently reported distinct responsiveness of GCB-like and ABC-like DLBCL cell lines to IL-4 stimulation. In GCB-like lymphoma cells, IL-4 leads to nuclear accumulation of phosphorylated signal transducer and activator of transcription 6 (STAT6) and induction of IL-4 target genes, while...