The v-src–and v-abl–transformed counterparts are instead IL-3–independent either for survival or cell growth. The parental cell line, the 32D/v-Abl–transformed cell line,23, 28 and the 32D/src–transformed cell line24 were transfected, by electroporation, either with the pRC/CMV ...
In the present report, we have examined the effects of expression of the c-fms, v-abl, or v-myc oncogene in a clonal hematopoietic progenitor cell line 32D cl 3. The 32D cell line is nonmalignant in vivo and is dependent upon a source of Interleukin-3 (IL-3) for growth in vitro...
p53-/- or p19ARF-/- MEFs were resistant to v-Abl-induced cell cycle arrest. Although wild-type MEFs were resistant to v-Abl transforming activity, p53-/- or p19ARF-/- MEFs were susceptible. The results indicate that loss of p19ARF and p53 function plays an important role during the ...
GV Borzillo,CJ Sherr - 《Mol.cell.biol》 被引量: 23发表: 1989年 c-abl的生物学特性及致白血病机制 篇首: -abl基因是Abelson小鼠白血病病毒癌基因v-abl在人 类细胞中的同源物,位于9号染色体,编码相对分子质量为 145×103的蛋白质,具有非受体酪氨酸激酶活性.c-abl在进 ... 赖忠彬,孙关林 - 《中华...
Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo. J Cell Mol Med. 2010 Jun;14(6B):1408-18. doi: 10.1111/j.1582-4934.2009.00902.x(IF:4.6580). Ver.CN20230327...
RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and differentiation through interactions with multiple effector protei... PY Ting,CW Johnson,C Fang,... - 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology》 被引量...
英文: Distribution and significance of p 53, c fos and c Abl oncogene protein in giant cell tumor of bone中文: 骨巨细胞瘤中p53,c-fos和c-Abl基因蛋白的分布及意义 英文: A Research Immunobead Assay for Flow Cytometric Detection of BCR-ABL Fusion Proteins中文: 免疫微球检测技术---用于BCR-ABL...
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Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line. P, Evans CA, Whetton AD: Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line. ... PJ Owen,P...
The presence of each oncogene in ascites cells was verified by immunohistochemistry or RT-PCR. This study provides evidence for the cooperativity of an unexpected pair of oncogenes in B cell immortalization. Related ReferencesKomatsubara, S.; Mori, K.; Hatanaka, M.; Amagai, T.; Inaba, K.; ...