长达5.1年的随访结果显示,R-CHOP加雷利度胺治疗DLBCL的疗效非常好,特别是对于ABC型DLBCL,远期生存可以达到与GCB型DLBCL相似的结果。 长达5.1年的随访数据显示,GCB型 vs ABC型的DLBCL在5年无进展生存期、总生存期分别为62.3% vs 70.8%和76% vs 74.8%,两组无显着差异。相比之下,单用R-CHOP方案治疗远期疗效较差...
At a probability cutoff of 0.9, 20 patients were classified as ABC, 40 were classified as GCB and 9 could not be classified (i.e. "type III DLBCL"). As expected from published studies, the differences in progression free survival (PFS) and overall survival (OS) of these ABC vs. GCB ...
EP: 16.Next Steps Using Anti-CD19 Therapies in DLBCLMarin F. Xavier, MD: For your practice, do you do anything different for germinal center vs activated B-cell [ABC] types in the frontline setting?John M. Burke, MD: I don’t. A number of attempts have been made to develop drugs ...
根据细胞起源(Cell-of-origin, COO)的不同将DLBCL分为3类,即生发中心B细胞样(Germinal center B-cell like, GCB)亚型、活化B细胞样(Activated B cell-like,ABC)亚型和其它第3亚型[1]。基于利妥昔单抗(Rituximab)的免疫化疗R-CHOP为DLBCL的标准一线治疗方案,约60%的患者可获得长期生存,GCB亚型预后优于ABC亚型...
这项研究证实,不同分子亚型的DLBLC在经RB-CHOP方案治疗时效果存在差异。ABC和MHG亚型的患者在接受硼替佐米治疗后可观察到PFS获益,ABC组患者的OS也出现改善(60个月PFS差异15%;OS差异13%),但在GCB组中则未观察到PFS和OS的改善。 这项研究是在DLBLC患者中使用GEP进行实时分层的最大的研究之一。,但MHG型DLBCL在...
目的:这项回顾性研究比较了使用冷冻保存与新鲜采集的PBMCs培养制备CD19 CAR-T细胞治疗弥漫性大B细胞淋巴瘤(DLBCL)患者的安全性、有效性和不良反应。 方法:2019年1月至2023年4月,共纳入162例接受CD19-CD3zeta-4-1BB CAR-T细胞治...
We have recently reported distinct responsiveness of GCB-like and ABC-like DLBCL cell lines to IL-4 stimulation. In GCB-like lymphoma cells, IL-4 leads to nuclear accumulation of phosphorylated signal transducer and activator of transcription 6 (STAT6) and induction of IL-4 target genes, while...
The present invention relates to a method for classifying a diffuse large B-cell lymphoma (DLBCL) of a subject into a GCB-DLBCL or into a ABC-DLBCL comprising the step of determining the expression level of 10 genes in a tumor tissue sample obtained from the subject by performing a Reverse...
The present invention relates to a method for classifying a diffuse large B-cell lymphoma (DLBCL) of a subject into a GCB-DLBCL or into a ABC-DLBCL comprising the step of determining the expression level of 10 genes in a tumor tissue sample obtained from the subject by performing a Reverse...
The present invention relates to a method for classifying a diffuse large B-cell lymphoma (DLBCL) of a subject into a GCB-DLBCL or into a ABC-DLBCL comprising the step of determining the expression level of 10 genes in a tumor tissue sample obtained from the subject by performing a Reverse...