AAV2/5- mediated NGF gene delivery protects septal cholinergic neurons following axotomy. Brain Res. 1061, 107-113.Wu K, Meyer EM, Bennett JA et al (2005) AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy. Brain Res 1061:107–113...
As five hypoxia-responsive elements (5HRE) help to release NGF in hypoxia position long-lasting and specifically, the adeno-associated virus (AAV) serves as a vector, providing a platform for nutrition support and controlled expression. In an ideal condition, we expected NSCs could also repair ...
An abstract of the article "Biodistribution and Safety Profile of CERE-110 (AAV2-NGF) Delivered to the Rodent Brain," by Mark Landers, Melissa Austin, Kevin Kwok, Eli Ketchum, Richard Lin and colleagues is presented.doi:10.1016/j.ymthe.2004.06.667Mark Landers...
Molecular TherapyBishop, Kathie M., et al. "527. CERE-110, an AAV2- based vector to deliver NGF, provides trophic activity to basal forebrain cholinergic neurons in rats and cynomolgous monkeys." Molecular Therapy 9 (2004): S199-S200....
Castle, Michael J.Baltanas, Fernando CalvoKovacs, ImreNagahara, Alan H.Bankiewicz, Krystof S.Barba, DavidTuszynski, Mark H.Elsevier ScienceAlzheimers & DementiaA. Blesch,Mark H. Tuszynski.NGF gene therapy for Alzheimer’’s disease. Experimental Neurology . 2006...