2021年12月,武汉大学泰康医学院(基础医学院)医学病毒学研究所夏宇尘教授课题组在期刊《Cellular and Molecular Gastroenterology and Hepatology》上发表题为“A Novel MouseModel Harboring Hepatitis B Virus Covalently Closed Circular DNA”的研究论文。该研究通过使用腺相关病毒载体(AAV)系统将复制缺陷的线性乙肝病毒基因...
参考文献 [1]. Wang Y, Guo L, Shi J, et al. Interferon stimulated immune profile changes in a humanized mouse model of HBV infection[J]. Nature Communications, 2023, 14(1): 7393.
The anti–hepatitis B (HBV) activity of JNJ-4964 was assessed preclinically in an adeno-associated virus vector expressing HBV (AAV/HBV) mouse model. Mice were treated orally with 2, 6 or 20 mg/kg of JNJ-4964 once-per-week for 12 weeks and then followed up for 4 weeks. At 6 ...
These suggest that the AAV-HBV/mouse model might be relevant to test drugs targeting HBV cccDNA regulation and persistence. GraphicalDisplay Omitted Highlights ? The HBV cccDNA was detected by Southern blotting in AAV-HBV transduced C57BL6 mice. ? A strategy was set up to distinguish the HBV ...
This effect is also observed in the AAV-HBV mouse model, which was used to investigate if two cycles of GalNAc-HBV-siRNA treatment could induce deeper declines in HBsAg levels or prevent rebound, and to provide insights into the liver immune microenvironment. Methods: C57Bl/6 mice were ...