2024年5月28日,北京大学基础医学院、北京大学心血管研究所、血管稳态与重构全国重点实验室郭宇轩研究员团队在Circulation杂志上发表题为“MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing”的论文[1]。该研究基于Cre-LoxP、CRISPR/Cas9等超敏DNA记录技术,发现AAV9-Tn...
[3] Bish LT, Morine K, Sleeper MM, et al. Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Human gene therapy. 2008;19(12):1359-1368.[4] Vandendriessche T, Thorrez L, Acosta-Sanchez A,...
Babu GJ, Del Re DP. AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis. Sci Rep. 2021 May 18;11(1):10553. doi: 10.1038/s41598-021-89989-5. PMID: 34006931; PMCID: PMC8131354.[
2、Ishikawa K, Tilemann L, Fish K, Hajjar RJ. Gene delivery methods in cardiac gene therapy. ...
[4]Bilal, Alina S et al. “Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation.” Circulation. 143,20(2021):2025-2027. doi:10.1161/CIRCULATIONAHA.120.052437 [5]Sun, Ji Su et al. “Ventromedial hypothalamic primary cilia control energy and skeleta...
The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor 病理性心脏肥大可导致心力衰竭。研究证实在促心肌肥厚途径中表皮生长因子受体(EGFR或ErbB1)是正调控因子,EGFR的稳定性、转运和激活主要受翻译后修饰的调控,然而其具体调控机制尚不完全清楚。研究表明去泛素化酶UCHL...
文章标题:SUMO1 regulates post-infarct cardiac repair based on cellular heterogeneity 杂志:Journal of Pharmaceutical Analysis IF:14 病毒工具:AAV9-CTnT-SUMO1-EGFP 注射方式:尾静脉注射,1×10^11 vg/小鼠,100 µl 检测时间:3周 图8 AAV9-CTnT尾静脉注射感染心脏[7] ...
2024年5月28日,北京大学基础医学院郭宇轩研究员团队在Circulation杂志上发表题为“MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing”的论文。该研究基于Cre-LoxP、CRISPR/Cas9等超敏DNA记录技术,发现AAV9-Tnnt2载体在肝脏中广泛泄漏表达,向AAV9-Tnnt2转基因的3’-...
1.Yamada KP, Tharakan S, Ishikawa K. Consideration of clinical translation of cardiac AAV gene therapy. Cell Gene Ther Insights. 2020 Jun;6(5):609-615. doi: 10.18609/cgti.2020.073. Epub 2020 May 14. PMID: 32774893; PMCID: PMC7406214. ...
先前的研究表明，TRAF7突变会导致先天性心脏缺陷和畸形。然而，TRAF7在病理性心肌肥厚发病机制中的分子机制尚不清楚。武汉大学人民医院唐其柱教授团队在Cardiovascular Research (IF 10.2)上发表文章“Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating ...