Adeno-associated virus (AAV) vectors are an efficient method of gene delivery to various tissues including the lung. Mouse models are often used as a preliminary preclinical model in order to advance AAV lung gene therapy vectors. In this chapter we describe an AAV purification protocol using ...
AAV-Mediated angiotensin 1-7 overexpression inhibits tumor growth of lung cancer In Vitro and In Vivo Ang-(1-7) inhibits lung cancer cell growth both in vitro and in vivo. However, the molecular mechanism of action is unclear and also the rapid degradation ... X Chen,S Chen,N Pei,......
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Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which disp
AAV-mediated gene editing lights up the lungZiying YanThomas J. LynchJohn F. Engelhardt
The disclosure also provides vectors (e.g. AAV vectors), recombinant AAV (rAAV) and pharmaceutical compositions comprising the polynucleotides described herein. The disclosure further provides a method of treating cancer in a subject, the method comprising administering to the subject a therapeutically...
INTERSTITIAL lung diseasesADENO-associated virusPHENOTYPIC plasticityWe have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGF尾1. Here, we provide an in-depth characterization of phenotypic and transcriptomic changes ...
(2007). Calculating expected lung deposition of aerosolized administration of AAV vector in human clinical studies. J. Gene Med. 9, 10-21.Leung K, Louca E, Munson K, Dutzar B, Anklesaria P, Coates AL: Calculating expected lung deposition of aerosolized administration of AAV vector in human...
AAV-Mediated angiotensin 1-7 overexpression inhibits tumor growth of lung cancer In Vitro and In Vivo 来自 NCBI 喜欢 0 阅读量: 89 作者:X Chen,S Chen,N Pei,Y Mao,S Wang,R Yan,N Bai,A Li,Y Zhang,H Du 摘要: Ang-(1-7) inhibits lung cancer cell growth both in vitro and in vivo...
Adeno-associated virus (AAV) vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantifies of such recombinant vectors in amounts that would be clinically useful for human gene therapy application. Stable, helper-free AAV ...