A549 is a lung cancer cell line with COSMIC ID: 905949 and Sanger ID: 369, and Cell Line Passport number SIDM00903 (Non-Small Cell Lung Cancer (NSCLC), Adenocarcinoma). The A549 cell line was established in 1972 by D.J. Giard et al, through an explant culture of adenocarcinomic lung ...
Establishment of a drug sensitivity panel using human lung cancer cell lines. Acta Med. Okayama 53:67-75(1999) PubMed=10536175; DOI=10.3892/ijo.15.5.927 Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J. Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma wit...
Characteristics Karyotype This is a hypotriploid human cell line with the modal chromosome number of 66, occurring in 24% of cells. Cells with 64 (22%), 65, and 67 chromosome counts also occurred at relatively high frequencies; the rate with higher ploidies was low at 0.4%. There were 6...
to culture A549 cells in different media over a long term and identify conditions for promoting alveolar type II differentiation characteristics in A549 cells[3] Perfil del ADN STR-PCR Data: Amelogenin: X,Y CSF1PO: 10,12 D13S317: 11 D16S539: 11,12 D5S818: 11 D7S820: 8,11 THO1:...
Characteristics Karyotype This is a hypotriploid human cell line with the modal chromosome number of 66, occurring in 24% of cells. Cells with 64 (22%), 65, and 67 chromosome counts also occurred at relatively high frequencies; the rate with higher ploidies was low at 0.4%. There were ...
A549-HHP, the resulting cell line, was more resistant and grew better then the parent cell line, and showed the following characteristics: (1) resistance to hydrogen peroxide, (2) resistance to NO, (3) growth with and without hydrogen peroxide, and (4) resistance to doxorubicin. Gene chip...
Studies have suggested that tumor growth and spread are driven by a minority of cancer cells that exhibit characteristics similar to those of normal stem cells, thus these cells are called cancer stem cells (CSCs). CSCs are believed to play an important role in initiating and promoting cancer....
The strong invasive and metastatic characteristics of lung cancer cells are responsible for the relatively high malignancy. The cell–cell adhesion system is involved in the regulation of invasion and metastasis of cancer cells, although the mechanism has not been fully clarified. The cell–cell ...
If it is true that TGF-b1 increases both stemness and migration characteristics, does TGF-b1 strengthen CSCs and/or induce also non-CSCs to become more stem and migrant? For this purpose, we sorted the A549 cell line for CD133 marker and SP phenotype, obtaining CSC sublines with CD133 ...
1.The changes in biological characteristics of lung adenocarcinoma A549 cells under two in vitro culture systems;两种体外培养条件下肺腺癌A549细胞生物学特性的变化 2.Effects of PI3K pathway on multicellular resistance of lung adenocarcinoma A549 cells via affecting cell apoptosis;磷脂酰肌醇3激酶信号通路影...