参考文献 [1]Allyl‐isatin suppresses cell viability,induces cell cycle arrest,and promotes cell apoptosis in hepatocellular carcinoma HepG2 cells.Weihua Bian;;Yukuan An;;Huiqing Qu;;Yue Yang;;Junhou Yang;;Yanyan Xu.Fundamental&Clinical Pharmacology,2016 [2]Melanoma therapy:Check the checkpoints.M...
cell cyclegrowth arrestBackground/Aim: Several studies have documented the effects of isothiocyanates (ITCs) on cancer prevention by inducing oxidative stress, activating apoptosis, affecting cell-cycle regulation, etc. Previously, we have shown that ITCs, administered at low concentrations by the means...
[9]GA0 J,YU H,GUO W,et al.The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cell[J].Cancer Cell Int,2018,18:102. [10]苏远婷,江从军,吴礼高,...
Wei et al., "Tubeimoside-1 inhibits growth via the induction of cell cycle arrest and apoptosis in human melanoma A375 cells," Bangladesh Journal of Pharmacology, vol. Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone Tsay, "Toxicogenomics of kojic acid on gene express...
ConclusionPolyphyllinⅠcan effectively induce A375 cell apoptosis by promoting the production of ROS in A375 cells and decreasing the mitochondrial membrane potential, and arrest A375 cells at G0/G1 phase by inhibiting the expression of PKM2 and Cyclin D1. KEYWORDS: Melanoma;Cell line, tumor;Ap...
cycle of human malignant melanomaA375 cells to appear GdGlphase arrest,inhibit cell proliferation.However the roleofcell cycle control point isdifferentin time.(6)The two intefferential fragmentsdesigned in this experiment areinvolvedin regulation ...
induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther, 2006, 318(2):484-489. 10. Krishnaswamy M, Purushothaman KK. Plumbagin: a study of its anticancer...
These observations indicate that curcumin combined with d-borneol inhibits A375 cell proliferation by inducing apoptosis and G2/M cell cycle arrest. Key words: curcumin; d-borneol; anti-proliferative; combined effects 收稿日期:2015-06-10 基金项目:广东省自然科学基金面上项目(2014A030313265);广东省...
Mechanistic studies uncovered MG132's dual regulatory capacity: (1) Through MDM2 inhibition, it activated p53/p21/caspase-3 axis while suppressing CDK2/Bcl2, triggering cell cycle arrest and DNA damage cascades; (2) MAPK pathway activation emerged as a critical apoptosis driver. Notably, western...
down-regulationanti-apoptoticfactorreductionandactivation ofBid;inaddition,P53andAKTalsocaninhibitorenhancetheregulatingfactorexpressionof theG0/G1phase,leadingtoG0/G1cellcyclearrest.Insummary,thesignalingpathwayof 5-HMF-inducedA375cellgrowthinhibitionwasobtained. Keywords:5-HMF;Westernblotting;pathways30 0引言...