The current studies not only shed light on thebiological functionof Annexin A1 in fibrosis but also provided a basis of understanding of Annexin A1 as potential therapeutic target for fibrosis. Unfortunately, however, there has been very little research about the underlying mechanism between Annexin ...
Collectively, our findings shed light on the complexity of distal and proximal RE contact loop formation and provides evidence for a key role of TFs in controlling transcriptional response through the 3D reconfiguration of the chromatin structure in animals and plants. Methods Plant material and ...
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The structural features identified in this study shed light on the effects of pathogenic point mutations on protein folding, inter-protein assembly and membrane interactions. Furthermore, mutations that disrupt the assembly interfaces and membrane binding of OPA1 cause mitochondrial fragmentation in cell-...
As an alternative, mass spectrometry is emerging as a powerful tool in the identification and quantitation of proteins and peptides. The method described here, referred to as proteotyping, is a proteomic method using trypsin digestion and tandem mass spectrometry that detects the most common ...
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(1997). For these reasons, it was expected that our ratings on these scales would correlate significantly with those previously pub- lished for overlapping objects. The manipulability ratings, on the other hand, were compared with ratings by Magnie et al. (2003) and Wolk et al. (2005). ...
We constructed a lentiviral vector carrying genes of ferritin heavy chain 1 (FTH1), near-infrared fluorescent protein (iRFP) and enhanced green fluorescent protein (egfp), and estab- lished the induced pluripotent stem cells (iPSCs) culture stably expressing these three reporter genes. These iPS...
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2). In NEPC, the FOXA1 promoter shed contacts with its regulatory region identified in PRAD15 and looped to a distinct NEPC-restricted super-enhancer (Fig. 2d). Both the distal super-enhancer and promoter were co-bound by FOXA1 and ASCL1, suggesting an auto-regulatory circuit that is ...