PAF is a very rare and slowly progressive α-synucleinopathy characterized by PAF such as orthostatic hypotension, hypohidrosis, constipation as well as urinary and sexual dysfunctions without motor dysfunctions29. To date, the pathogenesis of PAF remains unclear and there is currently no specific tr...
The term α-synucleinopathy unites a group of neurodegenerative diseases which share the pathological hallmark of fibrillary inclusions in which α-synuclein protein is the major component. The three most common members of this group are Parkinson’s disease (PD), dementia with Lewy bodies (DLB) a...
Parkinson’s disease dementia (PDD) and Dementia with Lewy bodies (DLB) are closely related diseases in the α-synucleinopathy family that comprise the second most common neurodegenerative dementia [53]. These and other α-synucleinopathies are characterized by the presence of cytoplasmic inclusions ...
However, commonly used α-synuclein seed amplification assays take ≥48 h to perform as applied to patients’ diagnostic biospecimens. Here, we report the development of a faster α-synuclein RT-QuIC assay that is as analytically sensitive as prior assays of this type, but can be completed ...
Fluoxetine, a selective serotonin reuptake inhibitor, has been shown to be protective in toxin-induced models of PD, however its effects in an in vivo transgenic model of α-synucleinopathy remain unclear. In this context, this study examined the effect of fluoxetine in the MBP1-hαsyn tg mi...
The present invention relates to methods for restoring fast axonal transport in a cell which expresses a pathological synuclein protein and for treating a synucleinopathy using a Protein Kinase C mu or Src-Family Tyrosine Kinase inhibitor.doi:US8618063 B2Scott Brady...
Thus, we directly tested if the synaptic and memory deficits in a mouse model of α-synucleinopathy (TgA53T) are mediated by tau. TgA53T mice exhibit progressive memory deficits associated with postsynaptic deficits in the absence of obvious neuropathological and neurodegenerative changes in the ...
AL Mougenot,S Nicot,A Bencsik,E Morignat,T Baron 摘要: Our aim in this study was to investigate experimentally the possible in vivo transmission of a synucleinopathy, using a transgenic mouse model (TgM83) expressing the human A53T mutated α-synuclein. Brain homogenates from old TgM83 mice...
Acta Pharmacol Sin 2007 May; 28 (5): 616–626 Full-length article A cell-based model of α-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease1 Da-long ZHAO2,3, Li-bo ZOU3, Lan-fang ZHOU2, Ping ZHU2,4, Hai-bo ZHU2,4 2Institute of Materia ...
Platelet miRNAs as early biomarkers for progression of idiopathic REM sleep behavior disorder to a synucleinopathy doi:10.1038/s41598-025-96926-3Isolated REM sleep behavior disorderLewy body disordersBiomarkersPlateletsMiRNA expressionIndividuals diagnosed with isolated REM sleep behavior disorder (IRBD) ...